Pediatric Nephrology

, Volume 29, Issue 9, pp 1633–1636 | Cite as

Arterial hypertension during treatment with triptorelin in a child with Williams–Beuren syndrome

  • Ekaterini Siomou
  • Chrysoula Kosmeri
  • Maria Pavlou
  • Antonios P. Vlahos
  • Maria I. Argyropoulou
  • Antigoni Siamopoulou
Brief Report



Arterial hypertension (AHT) is a common finding in children with Williams–Beuren syndrome (WBS). Although cardiovascular and renal abnormalities can explain the AHT in some patients with WBS, its etiology is not fully understood and most cases are considered idiopathic.


The case is reported of a 10-year-old girl with WBS who developed severe AHT during treatment with triptorelin, a long-lasting gonadotropin-releasing hormone (GnRH) analog, administered because of early normal puberty. Comprehensive diagnostic studies ruled out other known causes of AHT associated with WBS. After discontinuation of triptorelin, the blood pressure remained within the normal range for her age and height with no antihypertensive treatment on long-term follow-up. To the best of the authors’ knowledge, this is the first report of AHT associated with triptorelin administration in a child with WBS.


Clinicians should be aware of the possibility, although rare, of AHT developing during triptorelin administration in childhood, specifically in patients at increased risk of AHT, such as those with WBS.


Williams–Beuren syndrome Arterial hypertension Triptorelin Precocious puberty Gonadotropin-releasing hormone (GnRH) analog 


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Copyright information

© IPNA 2014

Authors and Affiliations

  • Ekaterini Siomou
    • 1
  • Chrysoula Kosmeri
    • 1
  • Maria Pavlou
    • 1
  • Antonios P. Vlahos
    • 1
  • Maria I. Argyropoulou
    • 2
  • Antigoni Siamopoulou
    • 1
  1. 1.Departments of PediatricsUniversity Hospital of IoanninaIoanninaGreece
  2. 2.Departments of RadiologyUniversity Hospital of IoanninaIoanninaGreece

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