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Pediatric Nephrology

, Volume 29, Issue 9, pp 1625–1631 | Cite as

Regional citrate anticoagulation for pediatric CRRT using integrated citrate software and physiological sodium concentration solutions

  • Jean-Michel LietEmail author
  • Emma Allain-Launay
  • Bénédicte Gaillard-LeRoux
  • François Barrière
  • Alexis Chenouard
  • Jean-Marc Dejode
  • Nicolas Joram
Original Article

Abstract

Background

In continuous renal replacement therapy (CRRT), regional citrate anticoagulation offers an attractive alternative to heparinization, especially for children with a high bleeding risk.

Methods

We report on a new management approach to CRRT using integrated citrate software and physiological sodium concentration solutions. Convective filtration was performed with pre-filter citrate anticoagulation using an 18 mmol/L citrate solution and a post-filter replacement fluid. The citrate flow rate was automatically adjusted to the blood flow rate by means of integrated citrate software. Similarly, calcium was automatically infused into children to maintain their blood calcium levels within normal range.

Results

Eleven CRRT sessions were performed (330 h) in seven critically ill children aged 3–15 years (extreme values 15–66 kg). Disease categories included sepsis with multiorgan dysfunction (n = 2) and hemolytic uremic syndrome (n = 5). Median effluent dose was 2.1  (extreme values 1.7–3.3) L/h/1.73 m2. No session had to be stopped because of metabolic complications. Calcium levels, both in the circuits and in the circulating blood of the children, remained stable and secure.

Conclusions

Regional citrate anticoagulation can be used in children with a body weight of >15 kg using integrated citrate software and commercially available solutions with physiological sodium concentrations in a safe, effective and convenient procedure.

Keywords

Continuous venovenous hemofiltration Children Citrate anticoagulation Acute kidney injury Continuous renal replacement therapy Pediatric intensive care 

Notes

Acknowledgments

We would especially like to thank the nurses who were involved in this project (Hemofiltration Workgroup).

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Copyright information

© IPNA 2014

Authors and Affiliations

  • Jean-Michel Liet
    • 1
    Email author
  • Emma Allain-Launay
    • 2
  • Bénédicte Gaillard-LeRoux
    • 1
  • François Barrière
    • 1
  • Alexis Chenouard
    • 1
  • Jean-Marc Dejode
    • 1
  • Nicolas Joram
    • 1
  1. 1. Unité de Réanimation Pédiatrique, Pôle Femme-Enfant-AdolescentCentre hospitalier universitaire (CHU) de NantesNantesFrance
  2. 2.Unité de Néphrologie Pédiatrique, Clinique Médicale Pédiatrique, Pôle Femme-Enfant-AdolescentCHU of NantesNantesFrance

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