Pediatric Nephrology

, Volume 29, Issue 4, pp 757–766

Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease

  • Marie-Lyne Fillion
  • Christine L. Watt
  • Indra R. Gupta
Review

Abstract

Vesicoureteric reflux (VUR) is a common congenital urinary tract defect that predisposes children to recurrent kidney infections. Kidney infections can result in renal scarring or reflux nephropathy defined by the presence of chronic tubulo-interstitial inflammation and fibrosis that is a frequent cause of end-stage renal failure. The discovery of mouse models with VUR and with reflux nephropathy has provided new opportunities to understand the pathogenesis of these conditions and may provide insight on the genes and the associated phenotypes that need to be examined in human studies.

Keywords

Vesicoureteric reflux Mouse models Reflux nephropathy Children 

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Copyright information

© IPNA 2014

Authors and Affiliations

  • Marie-Lyne Fillion
    • 1
  • Christine L. Watt
    • 1
  • Indra R. Gupta
    • 1
    • 2
    • 3
  1. 1.Department of Human GeneticsMcGill UniversityMontrealCanada
  2. 2.Department of Pediatrics, Division of NephrologyMontreal Children’s Hospital–McGill UniversityMontrealCanada
  3. 3.Research Institute of McGill University Health CentreMontrealCanada

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