Pediatric Nephrology

, Volume 29, Issue 4, pp 531–536

Bone morphogenetic protein signaling in nephron progenitor cells

  • Leif Oxburgh
  • Aaron C. Brown
  • Sree Deepthi Muthukrishnan
  • Jennifer L. Fetting
Review

DOI: 10.1007/s00467-013-2589-2

Cite this article as:
Oxburgh, L., Brown, A.C., Muthukrishnan, S.D. et al. Pediatr Nephrol (2014) 29: 531. doi:10.1007/s00467-013-2589-2

Abstract

Bone morphogenetic protein (BMP) signaling plays an essential role in many aspects of kidney development, and is a major determinant of outcome in kidney injury. BMP treatment is also an essential component of protocols for differentiation of nephron progenitors from pluripotent stem cells. This review discusses the role of BMP signaling to nephron progenitor cells in each of these contexts.

Keywords

Bone morphogenetic protein BMP Nephrogenesis Nephron progenitor cell Nephron differentiation Renal repair Embryonic stem cell differentiation 

Copyright information

© IPNA 2013

Authors and Affiliations

  • Leif Oxburgh
    • 1
  • Aaron C. Brown
    • 1
  • Sree Deepthi Muthukrishnan
    • 1
  • Jennifer L. Fetting
    • 1
  1. 1.Department of Molecular MedicineMaine Medical Center Research InstituteScarboroughUSA

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