Pediatric Nephrology

, Volume 28, Issue 1, pp 115–120 | Cite as

Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study

  • Ibrahim F. Shatat
  • Sherron M. Jakson
  • Amanda E. Blue
  • Mary A. Johnson
  • John K. Orak
  • Ram Kalpatthi
Original Article



The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).


Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.


Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m2 (range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38, P = 0.02).


Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.


Anemia Sickle cell Blood pressure monitoring Ambulatory Hypertension Pediatrics 


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Copyright information

© IPNA 2012

Authors and Affiliations

  • Ibrahim F. Shatat
    • 1
  • Sherron M. Jakson
    • 2
  • Amanda E. Blue
    • 1
  • Mary A. Johnson
    • 2
  • John K. Orak
    • 1
  • Ram Kalpatthi
    • 3
  1. 1.Division of Pediatric Nephrology and HypertensionMUSC Children’s HospitalCharlestonUSA
  2. 2.Division of Pediatric Hematology OncologyMUSC Children’s HospitalCharlestonUSA
  3. 3.Division of Pediatric HematologyChildren’s Mercy HospitalKansas CityUSA

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