Quality of life in children with end-stage renal disease based on a PedsQL ESRD module
- 729 Downloads
Health-related quality of life (HRQOL) is an essential subject for children with end-stage renal disease (ESRD) and their families.
We performed a cross-sectional investigation of HRQOL in children undergoing renal replacement therapies, such as dialysis and renal transplantation, using the 34-item Pediatric Quality of Life Inventory 3.0 End-Stage Renal Disease (PedsQL 3.0 ESRD) module. We assessed 92 ESRD patients aged 2–18 from four Korean university hospitals.
The male:female ratio was 44:48, and the most common cause of ESRD was chronic glomerulonephritis. Fifty-five children were treated by dialysis, and 37 received renal transplantation. Transplant patients had better HRQOL than dialysis patients in two domains in parent proxy reports: “About my kidney disease” and “Worry.” In child self-reports, transplant patients had better HRQOL than dialysis patients in one domain: Treatment problems. However, there were no significant differences in total QOL scores between peritoneal dialysis (PD) and transplant patients in child self-reports. In addition, there were differences in the ESRD module scores between child self- and parent proxy reports. Children usually reported better QOL than their parents. Child self-reports showed significantly higher QOL scores than parent proxy reports in the domains of General fatigue, Family & peer interaction, and Worry. Children on PD self-reported a significantly higher QOL than children on hemodialysis (HD).
The PedsQL 3.0 ESRD module may be useful as an ESRD-specific instrument to evaluate HRQOL in children; however, a larger, longitudinal prospective study is warranted.
KeywordsQuality of life Children End-stage renal disease
- 1.Goldstein SL, Graham N, Warady BA, Seikaly M, McDonald R, Burwinkle TM, Limbers CA, Varni JW (2008) Measuring health-related quality of life in children with ESRD: performance of the generic and ESRD-specific instrument of the Pediatric Quality of Life Inventory (PedsQL). Am J Kidney Dis 51:285–297PubMedCrossRefGoogle Scholar
- 11.Buyan N, Turkmen MA, Bilge I, Baskin E, Haberal M, Bilginer Y, Mir S, Emre S, Akman S, Ozkaya O, Fidan K, Alpay H, Kavukcu S, Sever L, Ozcakar ZB, Dogrucan N (2010) Quality of life in children with chronic kidney disease (with child and parent assessments). Pediatr Nephrol 25:1487–1496PubMedCrossRefGoogle Scholar
- 13.Marciano RC, Soares CM, Diniz JS, Lima EM, Silva JM, Canhestro MR, Gazzinelli A, Melo CC, Dias CS, Simoes e Silva AC, Correa H, Oliveira EA (2011) Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease. Pediatr Nephrol 26:281–290PubMedCrossRefGoogle Scholar
- 19.United States Renal Data System (1992) Comorbid conditions and correlations with mortality risk among 3,399 incident hemodialysis patients. Am J Kidney Dis 20(Suppl 2):32–38Google Scholar
- 22.Khan IH, Campbell MK, Cantarovich D, Catto GR, Delcroix C, Edward N, Fontenaille C, Fleming LW, Gerlag PG, van Hamersvelt HW, Henderson IS, Koene RA, Papadimitriou M, Ritz E, Russell IT, Stier E, Tsakiris D, MacLeod AM (1996) Survival on renal replacement therapy in Europe: is there a centre effect’? Nephrol Dial Transplant 11:300–307PubMedCrossRefGoogle Scholar