Pediatric Nephrology

, Volume 27, Issue 9, pp 1575–1582 | Cite as

Serum and urine acute kidney injury biomarkers in asphyxiated neonates

  • Kosmas Sarafidis
  • Eleni Tsepkentzi
  • Eleni Agakidou
  • Elisavet Diamanti
  • Anna Taparkou
  • Vasiliki Soubasi
  • Fotios Papachristou
  • Vasiliki Drossou
Original Article

Abstract

Background

We evaluated serum (s) cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) and urine (u) CysC, NGAL and kidney injury molecule-1 (KIM-1) as markers of acute kidney injury (AKI) in asphyxiated neonates.

Methods

AKI biomarkers were measured in 13 asphyxiated neonates born at ≥36 weeks gestational age (eight with AKI and five without AKI) and 22 controls. AKI was defined as serum creatinine ≥1.5 mg/dl for >24 h or rising values >0.3 mg/dl from day of life (DOL) 1. Biomarkers were measured on DOL 1, 3, and 10.

Results

Asphyxiated neonates had significantly higher sCysC on DOL 1 as well as sNGAL and uCysC and uNGAL (standardized to urine creatinine and absolute values) than controls at all time points. Compared to controls, significantly higher sNGAL, uCysC, and uNGAL values were observed in the asphyxia-AKI and asphyxia–no AKI subgroups. Regarding uKIM-1, only the absolute values were significantly higher in asphyxiated neonates (DOL 10). sNGAL, uCyst, and uNGAL had a significant diagnostic performance as predictors AKI on DOL 1.

Conclusions

sNGAL, uCysC, and uNGAL are sensitive, early AKI biomarkers, increasing significantly in asphyxiated neonates even in those not fulfilling AKI criteria. Their measurement on DOL 1 is predictive of post-asphyxia-AKI.

Keywords

Cystatin C Gelatinase-associated lipocalin Kidney injury molecule-1 Renal tubular damage Diagnostic performance 

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Copyright information

© IPNA 2012

Authors and Affiliations

  • Kosmas Sarafidis
    • 1
  • Eleni Tsepkentzi
    • 1
  • Eleni Agakidou
    • 1
  • Elisavet Diamanti
    • 1
  • Anna Taparkou
    • 2
  • Vasiliki Soubasi
    • 1
  • Fotios Papachristou
    • 2
  • Vasiliki Drossou
    • 1
  1. 1.1st Department of Neonatology, Medical SchoolAristotle University of ThessalonikiThessalonikiGreece
  2. 2.1st Department of Pediatrics, Medical SchoolAristotle University of ThessalonikiThessalonikiGreece

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