Ultrasound mass screening for congenital anomalies of the kidney and urinary tract
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There is a high incidence of congenital anomalies of the kidneys and urinary tract (CAKUT). Early diagnosis of these defects may allow the best medical and/or surgical treatment to be implemented as rapidly as possible, preventing or at least slowing down an evolution toward chronic kidney disease.
Ultrasound mass screening for kidney and urinary tract abnormalities in infants at 2 months of age was carried out in Salento, Italy. The centers involved in the study examined a total of 17,783 infants between January 1992 and December 2010.
A total of 171 CAKUT were identified in the course of the mass screening. The frequency of CAKUT was 0.96%. Vesicoureteral reflux (n = 39) was the most frequent renal abnormality found, followed by ureteropelvic junction obstruction (n = 33), ectopic kidney (n = 26), and renal dysplasia (n = 19). In addition, nephrogenic rests (n = 2), as well as several extra-renal pathologies, including abdominal neuroblastoma (n = 3), were diagnosed incidentally.
Ultrasound has been effective for early detection of renal and urinary tract anomalies. In addition, this screening has proved to be very useful for the early identification and management of both renal and extra-renal precancerous as well as cancerous lesions. However, most patients requiring surgery in this study (0.24%) would probably have been symptomatic and come to medical attention without routine screening. On the basis of our results screening is not justified.
KeywordsUltrasound urinary mass screening Congenital anomalies of the kidneys
Conflict of interest
None of the authors has any conflict of interest to declare.
- 5.US Renal Data System (USRDS) (2010) Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2010. Available at http://www.usrds.org/adr.htm Accessed 13 June 2011
- 6.North American Pediatric Renal Trials and Collaborative Studies, NAPRTCS 2011 annual report Available at https://web.emmes.com/study/ped/annlrept/annlrept.html Accessed 7 November 2011
- 9.American Academy of Pediatrics (1993) Recommendations for preventive pediatric health care. In: Policy reference guide: a comprehensive guide to AAP policy statement. American Academy of Pediatrics, Elk Grove VillageGoogle Scholar
- 20.[no authors listed](1993) Metropolitan Atlanta congenital defects program surveillance data, 1988–1991. Teratology 48:695–709Google Scholar
- 22.Sanna-Cherchi S, Ravani P, Corbani V, Parodi S, Haupt R, Piaggio G, Innocenti ML, Somenzi D, Trivelli A, Caridi G, Izzi C, Scolari F, Mattioli G, Allegri L, Ghiggeri GM (2009) Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int 76:528–533PubMedCrossRefGoogle Scholar