Pediatric Nephrology

, Volume 27, Issue 10, pp 1847–1854

Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules

  • Christopher Y. Lu
  • Pamela D. Winterberg
  • Jianlin Chen
  • John R. Hartono
Review

DOI: 10.1007/s00467-011-2029-0

Cite this article as:
Lu, C.Y., Winterberg, P.D., Chen, J. et al. Pediatr Nephrol (2012) 27: 1847. doi:10.1007/s00467-011-2029-0

Abstract

Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia–reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal–spatial roles and potential therapeutics targeting this particular receptor–ligand interaction are also explored.

Keywords

Ischemic acute kidney injury Innate immunity Damage associated molecular patterns Toll-like receptor Transplant rejection 

Copyright information

© IPNA 2011

Authors and Affiliations

  • Christopher Y. Lu
    • 1
  • Pamela D. Winterberg
    • 2
  • Jianlin Chen
    • 1
  • John R. Hartono
    • 1
  1. 1.Division of Nephrology, Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Division of Pediatric Nephrology, Department of PediatricsUniversity of Texas Southwestern Medical CenterDallasUSA

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