Pediatric Nephrology

, Volume 27, Issue 2, pp 243–249

High serum adiponectin concentration in children with chronic kidney disease

  • Kristina F. Möller
  • Christina Dieterman
  • Lena Herich
  • Ilka A. Klaassen
  • Markus J. Kemper
  • Dirk E. Müller-Wiefel
Original Article

Abstract

Adiponectin (ADPN) counteracts the inflammatory response of the endothelium, which plays an important role in the development of atherosclerosis in patients with chronic kidney disease (CKD). Data in children with CKD are scarce. We examined serum ADPN concentration in 90 children with various renal disorders: 28 with CKD on conservative treatment (CKD), 21 on regular dialysis treatment (D), and 41 after kidney transplantation (Tx); 27 age-matched healthy children served as controls (C). Body mass index (BMI), estimated glomerular filtration rate (eGFR), lipids, homocysteine, high sensitivity CRP (hsCRP), and systolic blood pressure (SBP) were also measured. Mean serum ADPN concentration was significantly higher in patients with CKD (27.3 μg/ml ±15.0), on D (34.2 μg/ml ±14.9), and after Tx (23.6 μg/ml ±9.5) compared with ADPN levels in C (13.5 μg/ml ±6.1) (p < 0.0001). Serum ADPN concentration was inversely related to BMI (p = 0.001) and SBP (p = 0.004). In the multiple linear regression analysis, only SBP remained independently associated with ADPN plasma levels. Data show that children with CKD have significantly higher serum ADPN, even after Tx. The protective antiarthrosclerotic effect of ADPN may be mediated by lower SBP, a finding that deserves further study.

Keywords

Adiponectin Uremic atherosclerosis Chronic kidney disease Dialysis treatment Kidney transplantation Systolic blood pressure 

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Copyright information

© IPNA 2011

Authors and Affiliations

  • Kristina F. Möller
    • 1
  • Christina Dieterman
    • 1
  • Lena Herich
    • 2
  • Ilka A. Klaassen
    • 1
  • Markus J. Kemper
    • 1
  • Dirk E. Müller-Wiefel
    • 1
  1. 1.Pediatric Nephrology, Klinik für Kinder- und JugendmedizinUniversitätsklinikum Hamburg EppendorfHamburgGermany
  2. 2.Institut für Medizinische Biometrie und Epidemiologie UKEHamburgGermany

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