Pediatric Nephrology

, 26:2041 | Cite as

Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood

  • Trine Tangeraas
  • Karsten Midtvedt
  • Milada Cvancarova
  • Asle Hirth
  • Per Morten Fredriksen
  • Sigve Tonstad
  • Gunhild Aker Isaksen
  • Anna Bjerre
Original Article
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Abstract

Limited knowledge exists on cardiorespiratory fitness (CR fitness) in adults having a renal transplant (Rtx) during childhood. Our aim was to assess CR fitness (V02peak) with a maximal treadmill test in former Rtx children reaching adulthood (ped-tx, n = 31), compared to patients Rtx as adults (adult-tx, n = 17) and healthy controls (HC, n = 36). Median age was 26.9 (19–41), 28.6 (23.5–34) and 33.5 (20–42) years, respectively. Median time since first Rtx was 18.1 (7–29) and 3.7 (1.2–12.6) years. Body composition was measured by dual-energy X-ray absorptiometry (DXA). V02peak was median 37.9 (12.5–56.3), 40.8 (26.5–57.5), and 44.4 (29.5–65.6) ml kg –1min –1 in the ped-tx, adult-tx, and HC, respectively. Ped-tx had significantly lower V02peak compared to HC (p = 0.01). Adult-tx had higher exercise capacity (test duration) compared to ped-tx (median 10.5 (7.5–16) and 9 (6–14) min, respectively (p = 0.016). In multiple linear regression analysis, test duration, fat-free mass (FFM, kg) and Hgb (g/dl) were significant predictors of V02peak explaining 86% of its variance. There was no significant difference between ped-tx and adult-tx in V02peak. CR fitness depicts long-term health outcome in Rtx patients both in regard to physical functioning and is a plausible indirect marker of CV health.

Keywords

Pediatric V02peak Physical activity Cardiovascular risk 
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Notes

Acknowledgments

The authors gratefully acknowledge participants for their valuable contributions to this study, and to Kari Gjersum and Mai-Britt Lynum for coordinating services. This study was supported by grants from the Foundation of Renée and Bredo Grimsgaard, Oslo, Norway.

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Copyright information

© IPNA 2011

Authors and Affiliations

  • Trine Tangeraas
    • 1
  • Karsten Midtvedt
    • 2
  • Milada Cvancarova
    • 3
  • Asle Hirth
    • 4
  • Per Morten Fredriksen
    • 1
  • Sigve Tonstad
    • 5
  • Gunhild Aker Isaksen
    • 6
  • Anna Bjerre
    • 1
  1. 1.Department of Paediatric Medicine, Women and Children’s DivisionOslo University Hospital RikshospitaletOsloNorway
  2. 2.Department of Organ TransplantationOslo University Hospital RikshospitaletOsloNorway
  3. 3.National Resource Center for Late Effects, Department of OncologyOslo University Hospital RikshospitaletOsloNorway
  4. 4.Department of PediatricsHaukeland University Hospital BergenOsloNorway
  5. 5.Division of Specialized Medicine and SurgeryOslo University Hospital RikshospitaletOsloNorway
  6. 6.Department of EndocrinologyOslo University Hospital RikshospitaletOsloNorway

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