Pediatric Nephrology

, Volume 27, Issue 5, pp 705–717

Monitoring and managing viral infections in pediatric renal transplant recipients

Review

Abstract

Viral infections remain a significant cause of morbidity and mortality following renal transplantation. The pediatric cohort is at high risk of developing virus-related complications due to immunological naiveté and the increased alloreactivity risk that requires maintaining a heavily immunosuppressive environment. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses may affect clinical outcome. Recent technological advances and novel antiviral therapy have allowed implementation of viral and immunological monitoring protocols and adoption of prophylactic or preemptive treatment approaches in high-risk groups. These strategies have led to improved viral infection management in the immunocompromised host, with significant impact on outcome. We review the major viral infections seen following kidney transplantation and discuss strategies for preventing and managing these pathogens.

Keywords

Cytomegalovirus Polyomavirus BK Epstein-Barr virus Quantitative DNA assays Cellular immunity Kidney transplantation 

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Copyright information

© IPNA 2011

Authors and Affiliations

  1. 1.Pediatric Hematology/Oncology and Research LaboratoriesPaviaItaly
  2. 2.Clinical and Experimental Kidney Transplantation UnitGenovaItaly
  3. 3.UOS Medicina Clinica e Sperimentale dei Trapianti d’Organo, Unità Operativa di NefrologiaIstituto G. GasliniGenovaItaly

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