Pediatric Nephrology

, Volume 25, Issue 11, pp 2303–2309 | Cite as

Intravenous fluid regimen and hyponatraemia among children: a randomized controlled trial

  • Lakshminarayanan Kannan
  • Rakesh LodhaEmail author
  • Subbiah Vivekanandhan
  • Arvind Bagga
  • Sushil K. Kabra
  • Madhulika Kabra
Original Article


The aim of this study was to compare the effect of three different intravenous (i.v.) fluid regimes on the incidence of hyponatraemia in hospitalized children ranging in age from 3 months to 12 years. Children who required the administration of i.v. maintenance fluid for at least 24 h following hospitalization were eligible for inclusion. The children were randomized to three i.v. fluid groups: Group A, 0.9% saline in 5% dextrose at the standard maintenance rate; Group B, 0.18% saline in 5% dextrose at the standard maintenance rate; Group C, 0.18% saline in 5% dextrose at two-thirds of the standard maintenance rate. The primary outcome measure was incidence of hyponatraemia (plasma sodium < 130 mEq/L). Of the 167 patients enrolled, 58, 56 and 53 patients were randomized to Group A, B and C, respectively. We observed that 14.3% (8/56) of the children administered 0.18% saline in 5% dextrose at the standard maintenance rate (Group B) developed hyponatraemia compared with 1.72% of the children in Group A and 3.8% of those in Group C. Based on these results, we conclude that the administration of 0.9% saline in 5% dextrose as i.v. maintenance fluid helps in reducing the incidence of hospital-acquired hyponatraemia among children.


Hyponatraemia Intravenous fluids Incidence Hypernatraemia Maintenance 


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Copyright information

© IPNA 2010

Authors and Affiliations

  • Lakshminarayanan Kannan
    • 1
  • Rakesh Lodha
    • 1
    Email author
  • Subbiah Vivekanandhan
    • 2
  • Arvind Bagga
    • 1
  • Sushil K. Kabra
    • 1
  • Madhulika Kabra
    • 1
  1. 1.Department of PediatricsAll India Institute of Medical SciencesAnsari NagarIndia
  2. 2.Department of NeurobiochemistryAll India Institute of Medical SciencesAnsari NagarIndia

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