Pediatric Nephrology

, Volume 26, Issue 2, pp 165–180 | Cite as

Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis

  • T. Matthew Eison
  • Bettina H. Ault
  • Deborah P. Jones
  • Russell W. Chesney
  • Robert J. WyattEmail author


Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and intriguing conditions in the discipline of pediatric nephrology. Although the eventual outcome is excellent in most cases, PSAGN remains an important cause of acute renal failure and hospitalization for children in both developed and underdeveloped areas. The purpose of this review is to describe both the typical and less common clinical features of PSAGN, to outline the changes in the epidemiology of PSAGN over the past 50 years, and to explore studies on the pathogenesis of the condition with an emphasis on the search for the elusive nephritogenic antigen.


Acute glomerulonephritis Group A beta-hemolytic streptococcus Nephritogenic 


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Copyright information

© IPNA 2010

Authors and Affiliations

  • T. Matthew Eison
    • 1
  • Bettina H. Ault
    • 1
  • Deborah P. Jones
    • 1
  • Russell W. Chesney
    • 1
  • Robert J. Wyatt
    • 1
    Email author
  1. 1.Division of Pediatric Nephrology, Department of PediatricsUniversity of Tennessee Health Science Center, and the Children’s Foundation Research Center at Le Bonheur Children’s Medical CenterMemphisUSA

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