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Pediatric Nephrology

, Volume 26, Issue 2, pp 165–180 | Cite as

Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis

  • T. Matthew Eison
  • Bettina H. Ault
  • Deborah P. Jones
  • Russell W. Chesney
  • Robert J. Wyatt
Review

Abstract

Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and intriguing conditions in the discipline of pediatric nephrology. Although the eventual outcome is excellent in most cases, PSAGN remains an important cause of acute renal failure and hospitalization for children in both developed and underdeveloped areas. The purpose of this review is to describe both the typical and less common clinical features of PSAGN, to outline the changes in the epidemiology of PSAGN over the past 50 years, and to explore studies on the pathogenesis of the condition with an emphasis on the search for the elusive nephritogenic antigen.

Keywords

Acute glomerulonephritis Group A beta-hemolytic streptococcus Nephritogenic 

References

  1. 1.
    Wells CD (1812) Observations on the dropsy which succeeds scarlet fever. Trans Soc Imp Med Chir Knowledge 3:167–186Google Scholar
  2. 2.
    Bright R (1836) Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guy Hosp Rep 1:338–341Google Scholar
  3. 3.
    Peitzman SJ (2007) Dropsy, dialysis, transplant. A short history of failing kidneys. Johns Hopkins University Press, BaltimoreGoogle Scholar
  4. 4.
    Klebs MR: Cited by Charcot JM (1878) Lectures on Bright’s disease of the kidneys, translated by Millard HB. New York, William Wood & CoGoogle Scholar
  5. 5.
    Longcope WT, O’Brien DP, McGuire J, Hansen OC, Denny ER (1927) Relationship of acute infections to glomerular nephritis. J Clin Invest 5:7–30PubMedGoogle Scholar
  6. 6.
    Reichel H (1905) Uber Nephritis bei Scharlach. Z Heil 6:72–78Google Scholar
  7. 7.
    Dick GF, Dick GH (1924) Experimental scarlet fever. J Am Med Assoc 81:1166–1167Google Scholar
  8. 8.
    Dochez AR, Sherman L (1924) The significance of Streptococcus hemolyticus in scarlet fever and the preparation of a specific antiscarlatinal serum by immunization of the horse to Streptococcus hemolyticus scarlatinae. J Am Med Assoc 82:542–544Google Scholar
  9. 9.
    Longcope WT (1936) Studies of the variations in the antistreptolysin titer of the blood serum from patients with hemorrhagic nephritis. II. Observations on patients suffering from streptococcal infections, rheumatic fever and acute and chronic hemorrhagic nephritis. J Clin Invest 15:277–294PubMedGoogle Scholar
  10. 10.
    Kohler PF, Ten Bensel R (1969) Serial complement component alterations in acute glomerulonephritis and systemic lupus erythematosus. Clin Exp Immunol 4:191–202PubMedGoogle Scholar
  11. 11.
    Futcher PH (1940) Glomerular nephritis following skin infections. Arch Intern Med 65:1192–1210Google Scholar
  12. 12.
    Lyttle JD, Seegal D, Loeb EN, Jost EL (1938) The serum antistreptolysin titer in acute glomerulonephritis. J Clin Invest 17:631–639PubMedGoogle Scholar
  13. 13.
    Seegal D, Earle DP (1941) A consideration of certain biological differences between glomerulonephritis and rheumatic fever. Am J Med Sci 201:528–539Google Scholar
  14. 14.
    Carapetis JR, Steer AC, Mulholland EK, Weber M (2005) The global burden of group A streptococcal diseases. Lancet Infect Dis 5:685–694PubMedGoogle Scholar
  15. 15.
    Sulyok E (2004) Acute proliferative glomerulonephritis. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 601–613Google Scholar
  16. 16.
    Ilyas M, Tolaymat A (2008) Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study. Pediatr Nephrol 23:1101–1106PubMedGoogle Scholar
  17. 17.
    Roy S 3rd, Stapleton FB (1990) Changing perspectives in children hospitalized with poststreptococcal acute glomerulonephritis. Pediatr Nephrol 4:585–588PubMedGoogle Scholar
  18. 18.
    Bisno AL, Pearce IA, Wall HP, Moody MD, Stollerman GH (1970) Contrasting epidemiology of acute rheumatic fever and acute glomerulonephritis. N Engl J Med 283:561–565PubMedGoogle Scholar
  19. 19.
    Rammelkamp CH Jr, Weaver RS (1953) Acute glomerulonephritis, the significance of the variations in the incidence of the disease. J Clin Invest 32:345–358PubMedGoogle Scholar
  20. 20.
    Stollerman GH (1971) Rheumatogenic and nephritogenic streptococci. Circulation 43:915–921PubMedGoogle Scholar
  21. 21.
    Lancefield RC (1928) The antigenic complex of Streptococcus haemolyticus. I. Demonstration of a type-specific substance in extracts of Streptococcus haemolyticus. J Exp Med 47:91–96PubMedGoogle Scholar
  22. 22.
    Widdowson JP, Maxted WR, Grant DL (1970) The production of opacity in serum by group A streptococci and its relationship with the presence of M antigen. J Gen Microbiol 61:343–353PubMedGoogle Scholar
  23. 23.
    Widdowson JP, Maxted WR, Grant DL, Pinney AM (1971) The relationship between M-antigen and opacity factor in group A streptococci. J Gen Microbiol 65:69–80PubMedGoogle Scholar
  24. 24.
    Cunningham MW (2000) Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13:470–511PubMedGoogle Scholar
  25. 25.
    Kwong YL, Chan KW, Chan MK (1987) Acute post-streptococcal glomerulonephritis followed shortly by acute rheumatic fever. Postgrad Med J 63:209–210PubMedGoogle Scholar
  26. 26.
    Matsell DG, Baldree LA, DiSessa TG, Gaber LS, Stapleton FB (1990) Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. Child Nephrol Urol 10:112–114PubMedGoogle Scholar
  27. 27.
    Dillon HC Jr (1967) Pyoderma and nephritis. Annu Rev Med 18:207–218PubMedGoogle Scholar
  28. 28.
    Updyke EL, Moore MS, Conroy E (1955) Provisional new type of group A streptococci associated with nephritis. Science 121:171–172PubMedGoogle Scholar
  29. 29.
    Parker MT, Bassett DC, Maxted WR, Arneaud JD (1968) Acute glomerulonephritis in Trinidad: serological typing of group A streptococci. J Hyg (Lond) 66:657–675Google Scholar
  30. 30.
    Stetson CA, Rammelkamp CH Jr, Krause RM, Kohen RJ, Perry WD (1955) Epidemic acute nephritis: studies on etiology, natural history and prevention. Medicine (Baltimore) 34:431–450Google Scholar
  31. 31.
    Anthony BF, Kaplan EL, Wannamaker LW, Briese FW, Chapman SS (1969) Attack rates of acute nephritis after type 49 streptococcal infection of the skin and of the respiratory tract. J Clin Invest 48:1697–1704PubMedGoogle Scholar
  32. 32.
    Fish AJ, Herdman RC, Michael AF, Pickering RJ, Good RA (1970) Epidemic acute glomerulonephritis associated with type 49 streptococcal pyoderma. II. Correlative study of light, immunofluorescent and electron microscopic findings. Am J Med 48:28–39PubMedGoogle Scholar
  33. 33.
    Berrios X, Lagomarsino E, Solar E, Sandoval G, Guzman B, Riedel I (2004) Post-streptococcal acute glomerulonephritis in Chile—20 years of experience. Pediatr Nephrol 19:306–312PubMedGoogle Scholar
  34. 34.
    Dillon HC Jr (1970) Streptococcal skin infection and acute glomerulonephritis. Postgrad Med J 46:641–652PubMedGoogle Scholar
  35. 35.
    Dillon HC Jr, Moody MD, Maxted WR, Parker MT (1967) The epidemiology of impetigo and acute glomerulonephritis. Results of serological typing of group A streptococci. Am J Epidemiol 86:710–723PubMedGoogle Scholar
  36. 36.
    Anand SK, Trygstad CW, Sharma HM, Northway JD (1975) Extracapillary proliferative glomerulonephritis in children. Pediatrics 56:434–442PubMedGoogle Scholar
  37. 37.
    Rodriguez-Iturbe B, Garcia R, Rubio L, Cuenca L, Treser G, Lange K (1976) Epidemic glomerulonephritis in Maracaibo. Evidence for progression to chronicity. Clin Nephrol 5:197–206PubMedGoogle Scholar
  38. 38.
    Reinstein CR (1955) Epidemic nephritis at Red Lake, Minnesota. J Pediatr 47:25–34PubMedGoogle Scholar
  39. 39.
    Schwartz B, Facklam RR, Breiman RF (1990) Changing epidemiology of group A streptococcal infection in the USA. Lancet 336:1167–1171PubMedGoogle Scholar
  40. 40.
    Roy S 3rd, Pitcock JA, Etteldorf JN (1976) Prognosis of acute poststreptococcal glomerulonephritis in childhood: prospective study and review of the literature. Adv Pediatr 23:35–69PubMedGoogle Scholar
  41. 41.
    Schick B (1912) Die Nachkrankheiten des Scharlach: pathogenese der Nachrankheiten. In: Escherich T, Schick B (eds) Scharlach. Holder, Leipzig, p 151Google Scholar
  42. 42.
    von Pirquet C (1911) Allergy. Arch Int Med 7:259–288Google Scholar
  43. 43.
    Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–920PubMedGoogle Scholar
  44. 44.
    Fish AJ, Michael AF, Vernier RL, Good RA (1966) Acute serum sickness nephritis in the rabbit. An immune deposit disease. Am J Pathol 49:997–1022PubMedGoogle Scholar
  45. 45.
    Germuth FG Jr (1953) A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med 97:257–282PubMedGoogle Scholar
  46. 46.
    Germuth FG Jr, Senterfit LB, Dreesman GR (1972) Immune complex disease. V. The nature of the circulating complexes associated with glomerular alterations in the chronic BSA-rabbit system. Johns Hopkins Med J 130:344–357PubMedGoogle Scholar
  47. 47.
    Nadasdy T, Silva FG (2007) Acute postinfectious glomerulonephritis and glomerulonephritis caused by persistent bacterial infection. In: Jennette JC, Olson JL, Schwartz MM, Silva FG (eds) Heptinstall’s pathology of the kidney, 6th edn. Lippincott Williams and Wilkins, Philadelphia, pp 322–396Google Scholar
  48. 48.
    Rodriguez-Iturbe B, Batsford S (2007) Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int 71:1094–1104PubMedGoogle Scholar
  49. 49.
    Rodriguez-Iturbe B, Carr RI, Garcia R, Rabideau D, Rubio L, McIntosh RM (1980) Circulating immune complexes and serum immunoglobulins in acute poststreptococcal glomerulonephritis. Clin Nephrol 13:1–4PubMedGoogle Scholar
  50. 50.
    Yoshizawa N, Treser G, McClung JA, Sagel I, Takahashi K (1983) Circulating immune complexes in patients with uncomplicated group A streptococcal pharyngitis and patients with acute poststreptococcal glomerulonephritis. Am J Nephrol 3:23–29PubMedGoogle Scholar
  51. 51.
    Mezzano S, Olavarria F, Ardiles L, Lopez MI (1986) Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. Clin Nephrol 26:61–65PubMedGoogle Scholar
  52. 52.
    Nordstrand A, Norgren M, Holm SE (1999) Pathogenic mechanism of acute post-streptococcal glomerulonephritis. Scand J Infect Dis 31:523–537PubMedGoogle Scholar
  53. 53.
    Walport MJ (2001) Complement. First of two parts. N Engl J Med 344:1058–1066PubMedGoogle Scholar
  54. 54.
    Jaffe R, Holz E (1948) Experimental allergic myocarditis. Exp Med Surg 6:189–202PubMedGoogle Scholar
  55. 55.
    Kendall FE, Heidelberger M, Dawson MH (1937) A serologically inactive polysaccharide elaborated by mucoid strains of group A hemolytic streptococci. J Biol Chem 118:61Google Scholar
  56. 56.
    Cavelti PA (1947) Studies on pathogenesis of rheumatic fever, experimental production of autoantibodies to heart, skeletal muscle and connective tissue. Arch Pathol 44:1–7Google Scholar
  57. 57.
    Frick E (1951) Animal experiments on an allergotuberculous myocarditis. Z Gesamte Exp Med 117:393–404PubMedGoogle Scholar
  58. 58.
    Kaplan MH (1958) Immunologic studies of heart tissue. I. Production in rabbits of antibodies reactive with an autologous myocardial antigen following immunization with heterologous heart tissue. J Immunol 80:254–267PubMedGoogle Scholar
  59. 59.
    Kaplan MH, Meyeserian M (1962) An immunological cross-reaction between group-A streptococcal cells and human heart tissue. Lancet 1:706–710PubMedGoogle Scholar
  60. 60.
    Christensen P, Schalen C, Holm SE (1979) Reevaluation of experiments intended to demonstrate immunological cross-reactions between mammalian tissues and streptococci. Prog Allergy 26:1–41PubMedGoogle Scholar
  61. 61.
    Kefalides NA, Ohno N, Wilson CB, Fillit H, Zabriski J, Rosenbloom J (1993) Identification of antigenic epitopes in type IV collagen by use of synthetic peptides. Kidney Int 43:94–100PubMedGoogle Scholar
  62. 62.
    Markowitz AS, Lange CF Jr (1964) Streptococcal related glomerulonephritis. I. Isolation, immunochemistry and comparative chemistry of soluble fractions from type 12 nephritogenic streptococci and human glomeruli. J Immunol 92:565–575PubMedGoogle Scholar
  63. 63.
    Holm SE (1967) Precipitinogens in beta-hemolytic streptococci and some related human kidney antigens. Acta Pathol Microbiol Scand 70:79–94PubMedGoogle Scholar
  64. 64.
    Holm SE, Braun D, Jonsson J (1968) Antigenic factors common to human kidney and nephritogenic and non-nephritogenic streptococcal strains. Int Arch Allergy Appl Immunol 33:127–130PubMedGoogle Scholar
  65. 65.
    Kingston D, Glynn LE (1971) A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes. Immunology 21:1003–1016PubMedGoogle Scholar
  66. 66.
    Kraus W, Beachey EH (1988) Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg. Proc Natl Acad Sci USA 85:4516–4520PubMedGoogle Scholar
  67. 67.
    Robinson JH, Kehoe MA (1992) Group A streptococcal M proteins: virulence factors and protective antigens. Immunol Today 13:362–367PubMedGoogle Scholar
  68. 68.
    Kantor FS (1965) Fibrinogen precipitation by streptococcal M protein. I. Identity of the reactants, and stoichiometry of the reaction. J Exp Med 121:849–859PubMedGoogle Scholar
  69. 69.
    Kaplan MH (1958) Localization of streptococcal antigens in tissues. I. Histologic distribution and persistence of M protein, types 1, 5, 12, and 19 in the tissues of the mouse. J Exp Med 107:341–352PubMedGoogle Scholar
  70. 70.
    Treser G, Semar M, McVicar M, Franklin M, Ty A, Sagel I, Lange K (1969) Antigenic streptococcal components in acute glomerulonephritis. Science 163:676–677PubMedGoogle Scholar
  71. 71.
    Balter S, Benin A, Pinto SW, Teixeira LM, Alvim GG, Luna E, Jackson D, LaClaire L, Elliott J, Facklam R, Schuchat A (2000) Epidemic nephritis in Nova Serrana, Brazil. Lancet 355:1776–1780PubMedGoogle Scholar
  72. 72.
    Francis AJ, Nimmo GR, Efstratiou A, Galanis V, Nuttall N (1993) Investigation of milk-borne Streptococcus zooepidemicus infection associated with glomerulonephritis in Australia. J Infect 27:317–323PubMedGoogle Scholar
  73. 73.
    McIntosh RM, Kulvinskas C, Kaufman DB (1971) Alteration of the chemical composition of human immunoglobulin G by Streptococcus pyogenes. J Med Microbiol 4:535–538PubMedGoogle Scholar
  74. 74.
    McIntosh RM, Kaufman DB, McIntosh JR, Griswold W (1972) Glomerular lesions produced by autologous serum and autologous IgG modified by treatment with a culture of a-haemolytic streptooccus. J Med Microbiol 5:1–7PubMedGoogle Scholar
  75. 75.
    Mosquera J, Rodriguez-Iturbe B (1984) Extracellular neuraminidase production of streptococci associated with acute nephritis. Clin Nephrol 21:21–28PubMedGoogle Scholar
  76. 76.
    Sesso RC, Ramos OL, Pereira AB (1986) Detection of IgG-rheumatoid factor in sera of patients with acute poststreptococcal glomerulonephritis and its relationship with circulating immunecomplexes. Clin Nephrol 26:55–60PubMedGoogle Scholar
  77. 77.
    McIntosh RM, Garcia R, Rubio L, Rabideau D, Allen JE, Carr RI, Rodriguez-Iturbe B (1978) Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. Kidney Int 14:501–510PubMedGoogle Scholar
  78. 78.
    Potter EV, Shaughnessy MA, Poon-King T, Earle DP (1982) Streptococcal neuraminidase and acute glomerulonephritis. Infect Immun 38:1196–1202PubMedGoogle Scholar
  79. 79.
    Vogt A, Batsford S, Rodriguez-Iturbe B, Garcia R (1983) Cationic antigens in poststreptococcal glomerulonephritis. Clin Nephrol 20:271–279PubMedGoogle Scholar
  80. 80.
    Vogt A, Schmiedeke T, Stockl F, Sugisaki Y, Mertz A, Batsford S (1990) The role of cationic proteins in the pathogenesis of immune complex glomerulonephritis. Nephrol Dial Transplant 5(Suppl 1):6–9PubMedGoogle Scholar
  81. 81.
    Stinson MW, McLaughlin R, Choi SH, Juarez ZE, Barnard J (1998) Streptococcal histone-like protein: primary structure of hlpA and protein binding to lipoteichoic acid and epithelial cells. Infect Immun 66:259–265PubMedGoogle Scholar
  82. 82.
    Cronin WJ, Lange K (1990) Immunologic evidence for the in situ deposition of a cytoplasmic streptococcal antigen (endostreptosin) on the glomerular basement membrane in rats. Clin Nephrol 34:143–146PubMedGoogle Scholar
  83. 83.
    Lange K, Seligson G, Cronin W (1983) Evidence for the in situ origin of poststreptococcal glomerulonephritis: glomerular localization of endostreptosin and the clinical significance of the subsequent antibody response. Clin Nephrol 19:3–10PubMedGoogle Scholar
  84. 84.
    Lange K, Azadegan AA, Seligson G, Bovie RC, Majeed H (1988) Asymptomatic poststreptococcal glomerulonephritis in relatives of patients with symptomatic glomerulonephritis. Diagnostic value of endostreptosin antibodies. Child Nephrol Urol 9:11–15PubMedGoogle Scholar
  85. 85.
    Seligson G, Lange K, Majeed HA, Deol H, Cronin W, Bovie R (1985) Significance of endostreptosin antibody titers in poststreptococcal glomerulonephritis. Clin Nephrol 24:69–75PubMedGoogle Scholar
  86. 86.
    Cronin W, Deol H, Azadegan A, Lange K (1989) Endostreptosin: isolation of the probable immunogen of acute post-streptococcal glomerulonephritis (PSGN). Clin Exp Immunol 76:198–203PubMedGoogle Scholar
  87. 87.
    Yoshizawa N, Oshima S, Sagel I, Shimizu J, Treser G (1992) Role of a streptococcal antigen in the pathogenesis of acute poststreptococcal glomerulonephritis. Characterization of the antigen and a proposed mechanism for the disease. J Immunol 148:3110–3116PubMedGoogle Scholar
  88. 88.
    Yoshizawa N, Oshima S, Takeuchi A, Kondo S, Oda T, Shimizu J, Nishiyama J, Ishida A, Nakabayashi I, Tazawa K, Sakurai Y (1997) Experimental acute glomerulonephritis induced in the rabbit with a specific streptococcal antigen. Clin Exp Immunol 107:61–67PubMedGoogle Scholar
  89. 89.
    Nordstrand A, Norgren M, Holm SE (1996) An experimental model for acute poststreptococcal glomerulonephritis in mice. APMIS 104:805–816PubMedGoogle Scholar
  90. 90.
    Villarreal H Jr, Fischetti VA, van de Rijn I, Zabriskie JB (1979) The occurrence of a protein in the extracellular products of streptococci isolated from patients with acute glomerulonephritis. J Exp Med 149:459–472PubMedGoogle Scholar
  91. 91.
    Ohkuni H, Friedman J, van de Rijn I, Fischetti VA, Poon-King T, Zabriskie JB (1983) Immunological studies of post-streptococcal sequelae: serological studies with an extracellular protein associated with nephritogenic streptococci. Clin Exp Immunol 54:185–193PubMedGoogle Scholar
  92. 92.
    Mezzano S, Burgos E, Mahabir R, Kemeny E, Zabriskie JB (1992) Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. Clin Nephrol 38:305–310PubMedGoogle Scholar
  93. 93.
    Johnston KH, Zabriskie JB (1986) Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A. J Exp Med 163:697–712PubMedGoogle Scholar
  94. 94.
    Nordstrand A, Norgren M, Ferretti JJ, Holm SE (1998) Streptokinase as a mediator of acute post-streptococcal glomerulonephritis in an experimental mouse model. Infect Immun 66:315–321PubMedGoogle Scholar
  95. 95.
    Nordstrand A, McShan WM, Ferretti JJ, Holm SE, Norgren M (2000) Allele substitution of the streptokinase gene reduces the nephritogenic capacity of group A streptococcal strain NZ131. Infect Immun 68:1019–1025PubMedGoogle Scholar
  96. 96.
    Holm SE, Ferretti JJ, Simon D, Johnston K (1992) Deletion of a streptokinase gene eliminates the nephritogenic capacity of a type 49 strain. In: Orefici G (ed) New perspectives on streptococci and streptococcal infections. Proceedings of the XI Lancefield International Symposium. Gustav-Fischer-Verlag, New York, pp 261–263Google Scholar
  97. 97.
    Holm SE (1990) Hypothesis on the pathogenesis of post-streptococcal glomerulonephritis based on recent clinical and experimental research. Zentralbl Bakteriol 274:325–332PubMedGoogle Scholar
  98. 98.
    Holm SE (1988) The pathogenesis of acute post-streptococcal glomerulonephritis in new lights. Review article. APMIS 96:189–193PubMedGoogle Scholar
  99. 99.
    Holm SE, Bergholm AM, Johnston KH (1988) A streptococcal plasminogen activator in the focus of infection and in the kidneys during the initial phase of experimental streptococcal glomerulonephritis. APMIS 96:1097–1108PubMedGoogle Scholar
  100. 100.
    Poon-King R, Bannan J, Viteri A, Cu G, Zabriskie JB (1993) Identification of an extracellular plasmin binding protein from nephritogenic streptococci. J Exp Med 178:759–763PubMedGoogle Scholar
  101. 101.
    Gerlach D, Knoll H, Kohler W, Ozegowski JH, Hribalova V (1983) Isolation and characterization of erythrogenic toxins. V. Communication: identity of erythrogenic toxin type B and streptococcal proteinase precursor. Zentralbl Bakteriol Mikrobiol Hyg A 255:221–233PubMedGoogle Scholar
  102. 102.
    Kapur V, Topouzis S, Majesky MW, Li LL, Hamrick MR, Hamill RJ, Patti JM, Musser JM (1993) A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin. Microb Pathog 15:327–346PubMedGoogle Scholar
  103. 103.
    Musser JM, Stockbauer K, Kapur V, Rudgers GW (1996) Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1beta convertase) alters proteolytic activity and ablates zymogen processing. Infect Immun 64:1913–1917PubMedGoogle Scholar
  104. 104.
    Cu GA, Mezzano S, Bannan JD, Zabriskie JB (1998) Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis. Kidney Int 54:819–826PubMedGoogle Scholar
  105. 105.
    Batsford SR, Mezzano S, Mihatsch M, Schiltz E, Rodriguez-Iturbe B (2005) Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH? Kidney Int 68:1120–1129PubMedGoogle Scholar
  106. 106.
    Parra G, Rodriguez-Iturbe B, Batsford S, Vogt A, Mezzano S, Olavarria F, Exeni R, Laso M, Orta N (1998) Antibody to streptococcal zymogen in the serum of patients with acute glomerulonephritis: a multicentric study. Kidney Int 54:509–517PubMedGoogle Scholar
  107. 107.
    Rodriguez-Iturbe B, Musser JM (2008) The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 19:1855–1864PubMedGoogle Scholar
  108. 108.
    Yamakami K, Yoshizawa N, Wakabayashi K, Takeuchi A, Tadakuma T, Boyle MD (2000) The potential role for nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. Methods 21:185–197PubMedGoogle Scholar
  109. 109.
    Broeseker TA, Boyle MD, Lottenberg R (1988) Characterization of the interaction of human plasmin with its specific receptor on a group A streptococcus. Microb Pathog 5:19–27PubMedGoogle Scholar
  110. 110.
    Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD (2004) Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. J Am Soc Nephrol 15:1785–1793PubMedGoogle Scholar
  111. 111.
    Oda T, Yamakami K, Omasu F, Suzuki S, Miura S, Sugisaki T, Yoshizawa N (2005) Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. J Am Soc Nephrol 16:247–254PubMedGoogle Scholar
  112. 112.
    Fujino M, Yamakami K, Oda T, Omasu F, Murai T, Yoshizawa N (2007) Sequence and expression of NAPlr is conserved among group A streptococci isolated from patients with acute poststreptococcal glomerulonephritis (APSGN) and non-APSGN. J Nephrol 20:364–369PubMedGoogle Scholar
  113. 113.
    Gewurz H, Pickering RJ, Naff G, Snyderman R, Mergenhagen SE, Good RA (1969) Decreased properdin activity in acute glomerulonephritis. Int Arch Allergy Appl Immunol 36:592–598PubMedGoogle Scholar
  114. 114.
    Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (1988) Complement profiles in acute post-streptococcal glomerulonephritis. Pediatr Nephrol 2:219–223PubMedGoogle Scholar
  115. 115.
    Wyatt RJ, McAdams AJ, Forristal J, Snyder J, West CD (1979) Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Kidney Int 16:505–512PubMedGoogle Scholar
  116. 116.
    Matsell DG, Wyatt RJ, Gaber LW (1994) Terminal complement complexes in acute poststreptococcal glomerulonephritis. Pediatr Nephrol 8:671–676PubMedGoogle Scholar
  117. 117.
    Hisano S, Matsushita M, Fujita T, Takeshita M, Iwasaki H (2007) Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis. Pathol Int 57:351–357PubMedGoogle Scholar
  118. 118.
    Derrick CW, Reeves MS, Dillon HC Jr (1970) Complement in overt and asymptomatic nephritis after skin infection. J Clin Invest 49:1178–1187PubMedGoogle Scholar
  119. 119.
    Levy M, Sich M, Pirotzky E, Habib R (1985) Complement activation in acute glomerulonephritis in children. Int J Pediatr Nephrol 6:17–24PubMedGoogle Scholar
  120. 120.
    Sjoholm AG (1979) Complement components and complement activation in acute poststreptococcal glomerulonephritis. Int Arch Allergy Appl Immunol 58:274–284PubMedGoogle Scholar
  121. 121.
    Matsell DG, Roy S 3rd, Tamerius JD, Morrow PR, Kolb WP, Wyatt RJ (1991) Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. Am J Kidney Dis 17:311–316PubMedGoogle Scholar
  122. 122.
    Strife CF, McAdams AJ, McEnery PT, Bove KE, West CD (1974) Hypocomplementemic and normocomplementemic acute nephritis in children: a comparison with respect to etiology, clinical manifestations, and glomerular morphology. J Pediatr 84:29–38PubMedGoogle Scholar
  123. 123.
    Tina LU, D’Albora JB, Antonovych TT, Bellanti JA, Calcagno PL (1968) Acute glomerulonephritis associated with normal serum B1C-globulin. Am J Dis Child 115:29–36PubMedGoogle Scholar
  124. 124.
    Roy S 3rd, Murphy WM, Arant BS Jr (1981) Poststreptococcal crescenteric glomerulonephritis in children: comparison of quintuple therapy versus supportive care. J Pediatr 98:403–410PubMedGoogle Scholar
  125. 125.
    Wong W, Morris MC, Zwi J (2009) Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children. Pediatr Nephrol 24:1021–1026PubMedGoogle Scholar
  126. 126.
    Lewy JE, Salinas-Madrigal L, Herdson PB, Pirani CL, Metcoff J (1971) Clinico-pathologic correlations in acute poststreptococcal glomerulonephritis. A correlation between renal functions, morphologic damage and clinical course of 46 children with acute poststreptococcal glomerulonephritis. Medicine (Baltimore) 50:453–501Google Scholar
  127. 127.
    West CD, McAdams AJ (1998) Serum and glomerular IgG in poststreptococcal glomerulonephritis are correlated. Pediatr Nephrol 12:392–396PubMedGoogle Scholar
  128. 128.
    Dodge WF, Spargo BH, Travis LB, Srivastava RN, Carvajal HF, DeBeukelaer MM, Longley MP, Menchaca JA (1972) Poststreptococcal glomerulonephritis. A prospective study in children. N Engl J Med 286:273–278PubMedGoogle Scholar
  129. 129.
    Sarkissian A, Papazian M, Azatian G, Arikiants N, Babloyan A, Leumann E (1997) An epidemic of acute postinfectious glomerulonephritis in Armenia. Arch Dis Child 77:342–344PubMedGoogle Scholar
  130. 130.
    Bingler MA, Ellis D, Moritz ML (2007) Acute post-streptococcal glomerulonephritis in a 14-month-old boy: why is this uncommon? Pediatr Nephrol 22:448–450PubMedGoogle Scholar
  131. 131.
    Li Volti S, Furnari ML, Garozzo R, Santangelo G, Mollica F (1993) Acute post-streptococcal glomerulonephritis in an 8-month-old girl. Pediatr Nephrol 7:737–738PubMedGoogle Scholar
  132. 132.
    Addis T (1950) Glomerular nephritis: diagnosis and treatment. The Macmillan Company, New YorkGoogle Scholar
  133. 133.
    Schacht RG, Gallo GR, Gluck MC, Iqbal MS, Baldwin DS (1979) Irreversible disease following acute poststreptococcal glomerulonephritis in children. J Chronic Dis 32:515–524PubMedGoogle Scholar
  134. 134.
    Rodriguez-Iturbe B (1984) Epidemic poststreptococcal glomerulonephritis. Kidney Int 25:129–136PubMedGoogle Scholar
  135. 135.
    Burke EC, Titus JL (1966) Poststreptococcal acute glomerulonephritis in children. Med Clin North Am 50:1141–1158PubMedGoogle Scholar
  136. 136.
    Travis LB, Dodge WF, Beathard GA, Spargo BH, Lorentz WB, Carvajal HF, Berger M (1973) Acute glomerulonephritis in children. A review of the natural history with emphasis on prognosis. Clin Nephrol 1:169–181PubMedGoogle Scholar
  137. 137.
    Espinel CH, Gregory AW (1980) Differential diagnosis of acute renal failure. Clin Nephrol 13:73–77PubMedGoogle Scholar
  138. 138.
    Miller TR, Anderson RJ, Linas SL, Henrich WL, Berns AS, Gabow PA, Schrier RW (1978) Urinary diagnostic indices in acute renal failure: a prospective study. Ann Intern Med 89:47–50PubMedGoogle Scholar
  139. 139.
    Powell HR, Rotenberg E, Williams AL, McCredie DA (1974) Plasma renin activity in acute poststreptococcal glomerulonephritis and the haemolytic-uraemic syndrome. Arch Dis Child 49:802–807PubMedGoogle Scholar
  140. 140.
    Rodriguez-Iturbe B, Baggio B, Colina-Chourio J, Favaro S, Garcia R, Sussana F, Castillo L, Borsatti A (1981) Studies on the renin-aldosterone system in the acute nephritic syndrome. Kidney Int 19:445–453PubMedGoogle Scholar
  141. 141.
    Brouhard BH, Travis LB (1992) Acute postinfectious glomerulonephritis. In: Edelmann CM (ed) Pediatric kidney disease, 2nd edn. Little, Brown and Company, Boston, pp 1199–1221Google Scholar
  142. 142.
    Goodyer PR, de Chadarevian JP, Kaplan BS (1978) Acute poststreptococcal glomerulonephritis mimicking Henoch-Schönlein purpura. J Pediatr 93:412–415PubMedGoogle Scholar
  143. 143.
    Lau KK, Wyatt RJ, Gaber LW (2005) Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis 46:1140–1144PubMedGoogle Scholar
  144. 144.
    Matsukura H, Ohtsuki A, Fuchizawa T, Miyawaki T (2003) Acute poststreptococcal glomerulonephritis mimicking Henoch-Schönlein purpura. Clin Nephrol 59:64–65PubMedGoogle Scholar
  145. 145.
    Sanjad S, Tolaymat A, Whitworth J, Levin S (1977) Acute glomerulonephritis in children: a review of 153 cases. South Med J 70:1202–1206PubMedGoogle Scholar
  146. 146.
    James JA (1976) Acute glomerulonephritis. In: James JA (ed) Renal disease in childhood, 3rd edn. The C. V. Mosby Company, St. Louis, pp 191–213Google Scholar
  147. 147.
    Greenbaum LA, Kerlin BA, Van Why S, Punzalan RC, Trost BA, Pan CG, Scott JP (2003) Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia. Pediatr Nephrol 18:1301–1303PubMedGoogle Scholar
  148. 148.
    Lau KK, Hastings MC, Delos Santos NM, Gaber LW, Ault BH (2007) A child with post-streptococcal acute glomerulonephritis complicated by Coombs positive autoimmune hemolytic anemia. Internet J Nephrol 4Google Scholar
  149. 149.
    Alpert JJ, Pickering MR, Warren RJ (1966) Failure to isolate streptococci from children under the age of 3 years with exudative tonsillitis. Pediatrics 38:663–666PubMedGoogle Scholar
  150. 150.
    Markowitz M, Bruton HD, Kuttner AG, Cluff LE (1965) The bacteriologic findings, streptococcal immune response, and renal complications in children and impetigo. Pediatrics 35:393–404PubMedGoogle Scholar
  151. 151.
    Ayoub EM, Wannamaker LW (1962) Evaluation of the streptococcal deoxyribonuclease B and diphosphopyridine nucleotidase antibody tests in acute rheumatic fever and acute glomerulonephritis. Pediatrics 29:527–538Google Scholar
  152. 152.
    West CD, Northway JD, Davis NC (1964) Serum levels of beta-1C globulin, a complement component, in the nephritides, lipoid nephrosis, and other conditions. J Clin Invest 43:1507–1517PubMedGoogle Scholar
  153. 153.
    Perlman LV, Herdman RC, Kleinman H, Vernier RL (1965) Poststreptococcal glomerulonephritis. A ten-year follow-up of an epidemic. JAMA 194:63–70PubMedGoogle Scholar
  154. 154.
    Fujinaga S, Ohtomo Y, Mochizuki H, Murakami H, Shimizu T, Yamashiro Y, Kaneko K (2009) Rapidly progressive acute post-streptococcal glomerulonephritis in a child with IgA nephropathy. Pediatr Int 51:425–428PubMedGoogle Scholar
  155. 155.
    Hiki Y, Tamura K, Shigematsu H, Kobayashi Y (1991) Superimposition of poststreptococcal acute glomerulonephritis on the course of IgA nephropathy. Nephron 57:358–364PubMedGoogle Scholar
  156. 156.
    Lau KK, Delos Santos NM (2005) Post-infectious acute glomerulonephritis with predominant mesangial deposition of IgA. Clin Exp Nephrol 9:262–263PubMedGoogle Scholar
  157. 157.
    Derakhshan A (2002) Another case of acute poststreptococcal glomerulonephritis with recurrence. Pediatr Nephrol 17:462PubMedGoogle Scholar
  158. 158.
    Dodge WF, Spargo BH, Bass JA, Travis LB (1968) The relationship between the clinical and pathologic features of poststreptococcal glomerulonephritis. A study of the early natural history. Medicine (Baltimore) 47:227–267Google Scholar
  159. 159.
    Roy S 3rd, Wall HP, Etteldorf JN (1969) Second attacks of acute glomerulonephritis. J Pediatr 75:758–767PubMedGoogle Scholar
  160. 160.
    Watanabe T, Yoshizawa N (2001) Recurrence of acute poststreptococcal glomerulonephritis. Pediatr Nephrol 16:598–600PubMedGoogle Scholar
  161. 161.
    Becquet O, Pasche J, Gatti H, Chenel C, Abely M, Morville P, Pietrement C (2010) Acute post-streptococcal glomerulonephritis in children of French Polynesia: a 3-year retrospective study. Pediatr Nephrol 25:275–280PubMedGoogle Scholar
  162. 162.
    Dedeoglu IO, Springate JE, Waz WR, Stapleton FB, Feld LG (1996) Prolonged hypocomplementemia in poststreptococcal acute glomerulonephritis. Clin Nephrol 46:302–305PubMedGoogle Scholar
  163. 163.
    Butani L (2001) Prolonged hypocomplementaemia after post-streptococcal glomerulonephritis. Nephrol Dial Transplant 16:869PubMedGoogle Scholar
  164. 164.
    Payne D, Houtman P, Browning M (2008) Acute post-streptococcal glomerulonephritis associated with prolonged hypocomplementaemia. J Clin Pathol 61:1133–1135PubMedGoogle Scholar
  165. 165.
    Jennings RB, Earle DP (1961) Post-streptococcal glomerulo-nephritis: histopathologic and clinical studies of the acute, subsiding acute and early chronic latent phases. J Clin Invest 40:1525–1595PubMedGoogle Scholar
  166. 166.
    Chung WY, Kim YJ (2000) Expression of Ki-67 antigen using monoclonal antibody MIB-1 in children with post-streptococcal glomerulonephritis. Pediatr Nephrol 14:389–392PubMedGoogle Scholar
  167. 167.
    McCluskey RT, Vassalli P, Gallo G, Baldwin DS (1966) An immunofluorescent study of pathogenic mechanisms in glomerular diseases. N Engl J Med 274:695–701PubMedGoogle Scholar
  168. 168.
    Michael AF Jr, Drummond KN, Good RA, Vernier RL (1966) Acute poststreptococcal glomerulonephritis: immune deposit disease. J Clin Invest 45:237–248PubMedGoogle Scholar
  169. 169.
    Morel-Maroger L, Leathem A, Richet G (1972) Glomerular abnormalities in nonsystemic diseases. Relationship between findings by light microscopy and immunofluorescence in 433 renal biopsy specimens. Am J Med 53:170–184PubMedGoogle Scholar
  170. 170.
    Yoshizawa N, Suzuki Y, Oshima S, Takeuchi A, Kondo S, Ishida A, Nakabayashi I, Nishiyama J, Tazawa K, Sagel I (1996) Asymptomatic acute poststreptococcal glomerulonephritis following upper respiratory tract infections caused by Group A streptococci. Clin Nephrol 46:296–301PubMedGoogle Scholar
  171. 171.
    Sorger K, Gessler U, Hubner FK, Kohler H, Schulz W, Stuhlinger W, Thoenes GH, Thoenes W (1982) Subtypes of acute postinfectious glomerulonephritis. Synopsis of clinical and pathological features. Clin Nephrol 17:114–128PubMedGoogle Scholar
  172. 172.
    Kimmelstiel P, Kim OJ, Beres J (1962) Studies on renal biopsy specimens, with the aid of the electron microscope. II. Glomerulonephritis and glomerulonephrosis. Am J Clin Pathol 38:280–296PubMedGoogle Scholar
  173. 173.
    West CD, McAdams AJ (1998) Glomerular deposits and hypoalbuminemia in acute post-streptococcal glomerulonephritis. Pediatr Nephrol 12:471–474PubMedGoogle Scholar
  174. 174.
    Johnston F, Carapetis J, Patel MS, Wallace T, Spillane P (1999) Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. Pediatr Infect Dis J 18:327–332PubMedGoogle Scholar
  175. 175.
    Sagel I, Treser G, Ty A, Yoshizawa N, Kleinberger H, Yuceoglu AM, Wasserman E, Lange K (1973) Occurrence and nature of glomerular lesions after group A streptococci infections in children. Ann Intern Med 79:492–499PubMedGoogle Scholar
  176. 176.
    Dodge WF, Spargo BH, Travis LB (1967) Occurrence of acute glomerulonephritis in sibling contacts of children with sporadic acute glomerulonephritis. Pediatrics 40:1028–1030PubMedGoogle Scholar
  177. 177.
    Rodriguez-Iturbe B, Rubio L, Garcia R (1981) Attack rate of poststreptococcal nephritis in families. A prospective study. Lancet 1:401–403PubMedGoogle Scholar
  178. 178.
    Treser G, Ehrenreich T, Ores R, Sagel I, Wasserman E, Lange K (1969) Natural history of “apparently healed” acute poststreptococcal glomerulonephritis in children. Pediatrics 43:1005–1017PubMedGoogle Scholar
  179. 179.
    Clark G, White RH, Glasgow EF, Chantler C, Cameron JS, Gill D, Comley LA (1988) Poststreptococcal glomerulonephritis in children: clinicopathological correlations and long-term prognosis. Pediatr Nephrol 2:381–388PubMedGoogle Scholar
  180. 180.
    A report of the Southwest Pediatric Nephrology Study Group (1985) A clinico-pathologic study of crescentic glomerulonephritis in 50 children. Kidney Int 27:450–458Google Scholar
  181. 181.
    Srivastava RN, Moudgil A, Bagga A, Vasudev AS, Bhuyan UN, Sundraem KR (1992) Crescentic glomerulonephritis in children: a review of 43 cases. Am J Nephrol 12:155–161PubMedGoogle Scholar
  182. 182.
    Baldwin DS, Gluck MC, Schacht RG, Gallo G (1974) The long-term course of poststreptococcal glomerulonephritis. Ann Intern Med 80:342–358PubMedGoogle Scholar
  183. 183.
    Drachman R, Aladjem M, Vardy PA (1982) Natural history of an acute glomerulonephritis epidemic in children. An 11- to 12-year follow-up. Isr J Med Sci 18:603–607PubMedGoogle Scholar
  184. 184.
    Nissenson AR, Mayon-White R, Potter EV, Mayon-White V, Abidh S, Poon-King T, Earle DP (1979) Continued absence of clinical renal disease seven to 12 years after poststreptococcal acute glomerulonephritis in Trinidad. Am J Med 67:255–262PubMedGoogle Scholar
  185. 185.
    Potter EV, Abidh S, Sharrett AR, Burt EG, Svartman M, Finklea JF, Poon-King T, Earle DP (1978) Clinical healing two to six years after poststreptococcal glomerulonephritis in Trinidad. N Engl J Med 298:767–772PubMedGoogle Scholar
  186. 186.
    Baldwin DS (1977) Poststreptococcal glomerulonephritis. A progressive disease? Am J Med 62:1–11PubMedGoogle Scholar
  187. 187.
    Schacht RG, Gluck MC, Gallo GR, Baldwin DS (1976) Progression to uremia after remission of acute poststreptococcal glomerulonephritis. N Engl J Med 295:977–981PubMedGoogle Scholar
  188. 188.
    Bergner-Rabinowitz S, Ferne M (1978) Type distribution of beta-hemolytic streptococci in Israel: a 10-year study. J Infect Dis 138:152–159PubMedGoogle Scholar
  189. 189.
    Lasch EE, Frankel V, Vardy PA, Bergner-Rabinowitz S, Ofek I, Rabinowitz K (1971) Epidemic glomerulonephritis in Israel. J Infect Dis 124:141–147PubMedGoogle Scholar
  190. 190.
    Dale JB (2008) Current status of group A streptococcal vaccine development. Adv Exp Med Biol 609:53–63PubMedGoogle Scholar
  191. 191.
    Dale JB, Penfound T, Chiang EY, Long V, Shulman ST, Beall B (2005) Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes. Clin Diagn Lab Immunol 12:833–836PubMedGoogle Scholar
  192. 192.
    Sanjad S, Tolaymat A, Whitworth J, Levin S (1977) Acute glomerulonephritis in children: a review of 153 cases. South Med J 70:1202–1206PubMedGoogle Scholar
  193. 193.
    Popović-Rolović M, Kostić M, Antić-Peco A, Jovanović O, Popović D (1991) Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. Nephron 58:393–399PubMedGoogle Scholar
  194. 194.
    Herthelius M, Berg U (1999) Renal function during and after childhood acute poststreptococcal glomerulonephritis. Pediatr Nephrol 13:907–911PubMedGoogle Scholar
  195. 195.
    Kasahara T, Hayakawa H, Okubo S, Okugawa T, Kabuki N, Tomizawa S, Uchiyama M (2001) Prognosis of acute poststreptococcal glomerulonephritis (APSGN) is excellent in children, when adequately diagnosed. Pediatr Int 43:364–367PubMedGoogle Scholar

Copyright information

© IPNA 2010

Authors and Affiliations

  • T. Matthew Eison
    • 1
  • Bettina H. Ault
    • 1
  • Deborah P. Jones
    • 1
  • Russell W. Chesney
    • 1
  • Robert J. Wyatt
    • 1
  1. 1.Division of Pediatric Nephrology, Department of PediatricsUniversity of Tennessee Health Science Center, and the Children’s Foundation Research Center at Le Bonheur Children’s Medical CenterMemphisUSA

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