Pediatric Nephrology

, Volume 25, Issue 8, pp 1505–1511 | Cite as

Prevalence and clinical correlates of microalbuminuria in children with sickle cell disease

  • Lauren J. Becton
  • Ram V. Kalpatthi
  • Elizabeth Rackoff
  • Deborah Disco
  • John K. Orak
  • Sherron M. Jackson
  • Ibrahim F. ShatatEmail author
Original Article


Sickle cell disease (SCD) is associated with a large spectrum of renal abnormalities, one of which, microalbuminuria/proteinuria (MA/P), is a known predictor of end-stage renal disease. We studied 90 children with SCD (57% male; mean age 11.4 ± 5.2 years) to determine the prevalence and examine clinical correlates of MA/P. The average of two spot urine microalbumin-to-creatinine samples obtained 6 months apart was recorded. Medical records were reviewed for demographic and biochemical data. Medication use, resting office blood pressures (BP), vaso-occlusive pain crises (VOC), and monthly transfusions were recorded. Fourteen children (15.5%) had MA/P. Hemoglobin (Hb) levels were significantly lower in the children with MA than in those without MA/P (8.8 ± 1.1 vs. 9.8 ± 1.4 g/dL, respectively) and were significantly correlated with MA (rho = 0.24, p = 0.03). Children with MA were more likely to have abnormal BP (p = 0.058), with 5/14 being hypertensive or pre-hypertensive. In a multivariate logistic regression model of MA, both Hb and BP classification remained in the final model. MA is a simple screening biomarker of early kidney injury in children with SCD. Larger studies to evaluate predictive factors of MA and the relationship to BP are needed.


Hypertension Microalbuminuria Pediatrics Proteinuria Sickle cell disease 



We thank Dr. Joseph Flynn for his critical review of our manuscript.


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Copyright information

© IPNA 2010

Authors and Affiliations

  • Lauren J. Becton
    • 1
  • Ram V. Kalpatthi
    • 2
  • Elizabeth Rackoff
    • 3
  • Deborah Disco
    • 3
  • John K. Orak
    • 4
  • Sherron M. Jackson
    • 3
  • Ibrahim F. Shatat
    • 4
    • 5
    Email author
  1. 1.Department of PediatricsMedical University of South Carolina Children’s HospitalCharlestonUSA
  2. 2.Pediatric Hematology and OncologyChildren’s Mercy HospitalKansas CityUSA
  3. 3.Pediatric Hematology and OncologyMedical University of South Carolina Children’s HospitalCharlestonUSA
  4. 4.Pediatric NephrologyMedical University of South Carolina Children’s HospitalCharlestonUSA
  5. 5.Division of Nephrology, CSB-316MUSC Children’s HospitalCharlestonUSA

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