Pediatric Nephrology

, Volume 25, Issue 7, pp 1277–1284 | Cite as

The renal adverse effects of ibuprofen are not mediated by AQP2 water channels

  • Rachel Vieux
  • Marina Zelenina
  • Anita Aperia
  • Jean-Michel Hascoët
Original Article

Abstract

The aim of this study was to determine (1) whether ibuprofen treatment in very preterm infants causes an increase in the renal water channel aquaporin-2 (AQP2) activity in the collecting duct via prostaglandin synthesis inhibition and (2) whether AQP2 activity remains disturbed long after ibuprofen treatment has ended. This was a prospective study involving premature infants with a gestation age of 27–31 weeks who received treatment between December 2005 and August 2006 in a tertiary Neonatal Intensive Care Unit. Each ibuprofen-treated infant was matched to two controls. Renal glomerular and tubular function were evaluated weekly for 1 month, and urinary AQP2 was measured by immuno-dotting. In total, 166 longitudinal samples were analyzed in 36 infants. Median [interquartile range] gestational age and birthweight were 28 [27.0–29.5] weeks and 1160 [1041–1242] g, respectively. Perinatal factors were similar in both groups. Urine output was significantly decreased in the ibuprofen-treated infants during the treatment. The urinary AQP2 level decreased significantly from day 2 to day 7 in both groups and was similar thereafter for the first month of life in ibuprofen-treated and control groups. Based on our results, we conclude that ibuprofen-induced oligo-anuria is not associated with a change in AQP2 activity and that ibuprofen does not affect AQP2 activity during the first month of life in very preterm neonates.

Keywords

Aquaporin-2 Ibuprofen Neonatal Intensive Care Unit Patent ductus arteriosus Renal function 

Notes

Acknowledgments

This study was supported by an unrestricted grant of the French non-benefit APRESAN Association, and the French non-benefit Association des Chefs de Service, Nancy.

Statement of financial support

This study benefited from an unrestricted grant of the French non-benefit APRESAN Association.

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Copyright information

© IPNA 2010

Authors and Affiliations

  • Rachel Vieux
    • 1
    • 2
    • 3
  • Marina Zelenina
    • 2
    • 3
  • Anita Aperia
    • 2
    • 3
  • Jean-Michel Hascoët
    • 1
  1. 1.Neonatal DepartmentMaternite Regionale UniversitaireNancyFrance
  2. 2.Nordic Center of Excellence for Research in Water Imbalance Related Disorders (WIRED)Karolinska InstitutetStockholmSweden
  3. 3.Department of Women’s and Children’s HealthKarolinska InstitutetStockholmSweden

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