Pediatric Nephrology

, 25:165

C1q nephropathy in a child presenting with recurrent gross hematuria

  • Luke Taggart
  • Alexis Harris
  • Samir El-Dahr
  • Franca Iorember
Brief Report

DOI: 10.1007/s00467-009-1290-y

Cite this article as:
Taggart, L., Harris, A., El-Dahr, S. et al. Pediatr Nephrol (2010) 25: 165. doi:10.1007/s00467-009-1290-y

Abstract

C1q nephropathy is a rare glomerular disease characterized by mesangial immune deposits with dominant or codominant staining for C1q. The exact pathogenesis leading to the mesangial immune deposits of C1q remains unknown. C1q nephropathy often presents with proteinuria in the nephrotic range, with an unpredictable or poor response to corticosteroid therapy. It is seen more commonly in older children and young adults and is more common in African Americans compared with Caucasians. We present a 4-year-old African American girl who presented with recurrent gross hematuria in the absence of proteinuria or hypertension and whose renal biopsy demonstrated dominant mesangial deposits of C1q. We conclude that C1q nephropathy should be considered in patients who present with recurrent gross hematuria.

Keywords

C1q nephropathy Recurrent gross hematuria Immune complex glomerulopathy Proteinuria 

Copyright information

© IPNA 2009

Authors and Affiliations

  • Luke Taggart
    • 1
  • Alexis Harris
    • 2
  • Samir El-Dahr
    • 1
  • Franca Iorember
    • 1
  1. 1.Department of Pediatrics, Division of Pediatric NephrologyTulane University School of MedicineNew OrleansUSA
  2. 2.NephropathLittlerockUSA

Personalised recommendations