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Pediatric Nephrology

, 24:1901 | Cite as

Treatment-based literature of Henoch–Schönlein purpura nephritis in childhood

  • Marco Zaffanello
  • Vassilios Fanos
Review

Abstract

Considerable concern has been expressed on the importance of identifying an improved therapeutic protocol for use in the treatment of childhood Henoch–Schönlein purpura nephritis, primarily due to the unpredictable success shown to date in improving long-term renal outcome. This review focuses on published reports describing the outcomes of therapeutic approaches currently being used in the treatment of pediatric Henoch–Schönlein purpura nephritis, with the aim of providing information that will facilitate a treatment-based approach in children presenting with varying degrees of kidney disease. The conclusions of the authors of this review are that currently prescribed treatments of children affected by Henoch–Schönlein purpura nephritis are not adequately guided by evidence obtained in properly designed, randomized, placebo-controlled trials with outcome markers related to the progression to end stage renal disease (level I evidence). Moreover, firm evidence supporting the best practice to be applied with the aim of delaying the progression of kidney disease is still lacking.

Keywords

Children Evidence-based approach Glomerulonephritis Henoch–Schönlein purpura 

Abbreviations

ACEI

angiotensin converting enzyme inhibitor

AZA

azathioprine

CSA

cyclosporine A

CYCP

cyclophosphamide

ESRD

end stage renal disease

HSP

Henoch–Schönlein purpura

HSPN

Henoch–Schönlein purpura nephritis

MM

mycophenolate mofetil

MP

methylprednisolone

P-Exch

plasma exchange

PU

proteinuria

RCT

randomized controlled trial

Notes

Declaration of competing interests

The authors declare the absence of competing interests.

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Copyright information

© IPNA 2008

Authors and Affiliations

  1. 1.Department of Mother-Child and Biology-GeneticsUniversity of VeronaVeronaItaly
  2. 2.Department of Paediatrics, Neonatal Intensive Care UnitUniversity of CagliariCagliariItaly

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