Arterial stiffness in children after renal transplantation
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Long-term survival after successful transplantation is limited by cardiovascular disease. We studied changes in arterial function in children after renal transplantation. We measured pulse-wave velocity (PWV) and the augmentation index (AIX) as estimated from central pulse-wave analysis in 36 patients with a functioning kidney transplant (mean age 14 ± 3.4 years) and 49 healthy children (mean age 13.3 ± 3.3 years). Transplantation had been performed 4.3 ± 3.3 years prior to examination. Transplanted patients had a significantly higher mean PWV of 5.43 ± 0.9 m/s; controls 4.68 ± 0.7 m/s. Likewise, the AIX was significantly higher in patients (–14.3 ± 15.2) than in controls –26.3 ± 13.5. We found no significant associations with the degree of transplant dysfunction, glomerular filtration rate (GFR) loss, or dose of immunosuppressive medications; however, the AIX was associated with the serum calcium-phosphorus product, and PWV correlated with systolic blood pressure and age. This study suggests that subclinical arteriopathy is present in young transplant recipients.
KeywordsRenal transplantation Children Arterial stiffness Cardiovascular disease Pulse-wave analysis
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