Pediatric Nephrology

, Volume 23, Issue 9, pp 1545–1550

Improved left ventricular mass index in children after renal transplantation

  • Rachel Becker-Cohen
  • Amiram Nir
  • Efrat Ben-Shalom
  • Choni Rinat
  • Sofia Feinstein
  • Benjamin Farber
  • Yaacov Frishberg
Original Article

DOI: 10.1007/s00467-008-0855-5

Cite this article as:
Becker-Cohen, R., Nir, A., Ben-Shalom, E. et al. Pediatr Nephrol (2008) 23: 1545. doi:10.1007/s00467-008-0855-5
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Abstract

Left ventricular hypertrophy (LVH) is a risk factor for cardiovascular disease, and it is prevalent in children with end-stage renal disease (ESRD) and after renal transplantation (RTx) on cross-sectional studies. Our aim was to compare prospectively left ventricular mass index (LVMI) in children with ESRD, before and after RTx. Thirteen patients aged 1.5–15 years underwent echocardiogram prior to and at least 3 months after RTx, and again in the second year after transplantation. A control group consisted of children with ESRD who remained on dialysis. Systolic and diastolic blood pressure index decreased significantly over the study period only in the children who had undergone RTx. Mean LVMI in children with ESRD decreased from 45.4 ± 12.6 g/m2.7 to 34.9 ± 10.4 g/m2.7 after RTx (P = 0.001), but it remained unchanged in patients who remained on dialysis. The prevalence of LVH decreased from 54% to 8% (P = 0.03) after RTx. Systolic and diastolic blood pressure index were correlated with LVMI. Mean body mass index increased during the study period from 17.3 ± 2.5 to 20 ± 4.6 (P = 0.05); however, no correlation was found with LVMI. LVH in children with ESRD is potentially reversible after RTx, especially with good control of hypertension.

Keywords

Left ventricular hypertrophy Hypertension Renal transplantation Pediatric 

Copyright information

© IPNA 2008

Authors and Affiliations

  • Rachel Becker-Cohen
    • 1
    • 2
  • Amiram Nir
    • 2
    • 3
  • Efrat Ben-Shalom
    • 1
    • 2
  • Choni Rinat
    • 1
    • 2
  • Sofia Feinstein
    • 1
    • 2
  • Benjamin Farber
    • 2
    • 3
  • Yaacov Frishberg
    • 1
    • 2
  1. 1.Division of Pediatric NephrologyShaare Zedek Medical CenterJerusalemIsrael
  2. 2.The Hadassah Hebrew University School of MedicineJerusalemIsrael
  3. 3.Division of Pediatric CardiologyShaare Zedek Medical CenterJerusalemIsrael

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