Hypersensitivity to inulin (polyfructan) is a rare event; two cases of food allergy and some patients presenting with allergy and hypersensitivity after inulin infusion have been reported. An 11-year-old boy suffering from severe immunoglobulin (Ig)A nephropathy (IgAN) experienced both anaphylactic reaction and concomitant relapse of his nephropathy following inulin infusion, used for measuring glomerular filtration rate (GFR) 2 years after the appearance of his initial symptoms. Pruritus, wheezing and cough were observed during a first renal function test; results of prick and intradermal tests were negative for inulin. The patient presented with pallor, asthenia and oliguria when a second inulin infusion was performed under dexchlorpheniramine, leading to the immediate cessation of the infusion. He was readmitted 2 days later because of fatigue and nausea related to acute renal failure. A drug-induced acute interstitial nephritis was first suspected. However, due to the presence of macroscopic haematuria and proteinuria, a renal biopsy was performed and showed acute proliferative relapse of IgAN. The underlying mechanism of inulin hypersensitivity is not well known. We can hypothesize that inulin had activated the innate immune system. Inulin may, thus, have been the initiating event of the renal relapse, acting like an infection, in a patient with IgA-mediated immunological dysregulation.
Hypersensitivity IgA nephropathy Inulin
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Gay-Crosier F, Schreiber G, Hauser C (2000) Anaphylaxis from inulin in vegetables and processed food. N Engl J Med 342:1372PubMedCrossRefGoogle Scholar
Franck P, Moneret-Vautrin DA, Morisset M, Kanny G, Megret-Gabeaux ML, Olivier JL (2005) Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 136:155–158PubMedCrossRefGoogle Scholar
Rahn KH, Heidenreich S, Bruckner D (1999) How to assess glomerular function and damage in humans. J Hypertens 17:309–317PubMedCrossRefGoogle Scholar
Tkaczyk C, Jensen BM, Iwaki S, Gilfillan AM (2006) Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses. Immunol Allergy Clin North Am 26:427–450PubMedCrossRefGoogle Scholar