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Pediatric Nephrology

, Volume 23, Issue 6, pp 937–945 | Cite as

Long-term follow-up of renal function in patients after surgery for obstructive uropathy

  • Daniela MiklovicovaEmail author
  • Olga Cervenova
  • Andrea Cernianska
  • Zuzana Jancovicova
  • Ladislav Dedik
  • Alena Vasilenkova
Original Article

Abstract

In this prospective study, selected biochemical markers of glomerular and tubular function, proteinuria, and ultrasound findings in 62 pediatric patients who underwent surgery for obstructive uropathy were examined. Patients were younger than 12 months, normocreatininemic at the time of surgery, and examined at a mean age of 6.3 ± 0.9 years. Out of the markers tested, serum concentration of cystatin C was significantly higher in patients when compared with the control group (p < 0.001), and serum creatinine concentration was within reference interval in all patients. With respect to tubular function, 26% of patients had decreased concentration ability. Proteinuria was detected in 4.8% of patients. On ultrasound, 66.7% of kidneys after surgery had residual dilatation of the renal pelvis. The patients thrive well, and their somatic parameters do not differ from their peers. Half of the patients had one or more urinary tract infections from the date of surgery to the date of examination. Study results support the need for long-term nephrologic follow-up in patients after surgery for obstructive uropathy. The hypothesis that renal function in patients undergoing surgery aged younger than 3 or 6 months is better when compared with those aged 6 to 12 months has not been confirmed.

Keywords

Obstructive uropathy Prenatal screening Postnatal screening Glomerular filtration rate Tubular function Follow-up 

Notes

Acknowledgements

The authors are grateful to Professor C.H. Schrõder for his advice in the preparation of the manuscript. This study was supported by a grant VEGA1/0524/03 from the Slovak Ministry of Education.

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Copyright information

© IPNA 2008

Authors and Affiliations

  • Daniela Miklovicova
    • 1
    • 4
    Email author
  • Olga Cervenova
    • 1
  • Andrea Cernianska
    • 1
  • Zuzana Jancovicova
    • 1
  • Ladislav Dedik
    • 2
  • Alena Vasilenkova
    • 3
  1. 1.1st Department of PediatricsUniversity Children’s Hospital, Comenius University in BratislavaBratislavaSlovakia
  2. 2.Slovak University of Technology in BratislavaBratislavaSlovakia
  3. 3.Department of Clinical BiochemistryUniversity Children’s Hospital, Comenius University in BratislavaBratislavaSlovakia
  4. 4.1st Department of PediatricsUniversity Children’s HospitalBratislavaSlovakia

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