Pediatric Nephrology

, Volume 23, Issue 5, pp 749–755

Outcome of lupus nephritis in Iranian children: prognostic significance of certain features

  • Neamatollah Ataei
  • Manijeh Haydarpour
  • Abbas Madani
  • Seyed Taher Esfahani
  • Niloufar Hajizadeh
  • Mohammad Hasan Moradinejad
  • Taghi Gholmohammadi
  • Shahriar Arbabi
  • Marzieh Haddadi
Original Article

DOI: 10.1007/s00467-007-0713-x

Cite this article as:
Ataei, N., Haydarpour, M., Madani, A. et al. Pediatr Nephrol (2008) 23: 749. doi:10.1007/s00467-007-0713-x

Abstract

The objective of this study was to determine the clinical and histopathological features and outcome of children with lupus nephritis (LN). Of 84 children with systemic lupus erythematosus (SLE), we retrospectively studied 58 children (69%) under 15 years of age with biopsy-proven LN who had been followed between October 1989 and January 2005. The mean age at diagnosis or initial referral was 10.6 ± 2.25 years, and the mean follow-up was 5.3 ± 4.1 years. Class IV LN was observed in 34 (58.6%) patients. The 5-year patient and renal survival rates were 82.5 and 78.5%, respectively, in the total group, and 75 and 85.8%, respectively, in patients with Class IV LN. No independent predictor of unfavorable outcome, including renal histology, was detected by multivariate analysis. The mid-term patient and the renal survival rates of Iranian children with biopsy-proven LN are high. Within 5 years of follow-up, renal histology was not a predictor for survival.

Keywords

Children Lupus nephritis Outcome Prognostic factors 

Copyright information

© IPNA 2007

Authors and Affiliations

  • Neamatollah Ataei
    • 1
  • Manijeh Haydarpour
    • 1
  • Abbas Madani
    • 1
  • Seyed Taher Esfahani
    • 1
  • Niloufar Hajizadeh
    • 1
  • Mohammad Hasan Moradinejad
    • 1
  • Taghi Gholmohammadi
    • 1
  • Shahriar Arbabi
    • 1
  • Marzieh Haddadi
    • 1
  1. 1.Department of Pediatric Nephrology, The Children’s Hospital Medical Center, School of MedicineMedical Sciences/University of TehranTehranIran

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