Pediatric Nephrology

, Volume 23, Issue 6, pp 1001–1003

Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome—a case report

  • Katarzyna Kiliś-Pstrusińska
  • Anna Medyńska
  • Danuta Zwolińska
  • Grzegorz Dobaczewski
Brief Report


Nephrotic syndrome can occur as a consequence of, among others, malignancy. In this report we describe a 16-year-old boy with secondary nephrotic syndrome associated with lymphoepithelioma-like thymic carcinoma, an extremely rare subtype of thymic carcinoma with poor prognosis.


Thymic carcinoma Children Nephrotic syndrome 


  1. 1.
    Glassock RJ (2003) Secondary minimal change disease. Nephrol Dial Transplant 18:52–58CrossRefGoogle Scholar
  2. 2.
    Nash MA, Edelmann CM, Bernstein G, Barnett HL (2004) The nephrotic syndrome. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology. Lippincott Williams & Wilkins, Philadelphia, PA, pp 1247–1266Google Scholar
  3. 3.
    Nicolato A, Ferraresi P, Bontempini L, Tomazzoli L, Magarotto R, Gerosa M (2001) Multiple brain metastases from “lymphoepithelioma-like” thymic carcinoma: a combined stereotactic-radiosurgical approach. Surg Neurol 55:232–234PubMedCrossRefGoogle Scholar
  4. 4.
    Chalabreysse L, Etienne-Mastroianni B, Adeleine P, Cordier J-F, Greenland T, Thivolet-Bejui F (2004) Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. Histopathology 44:367–374PubMedCrossRefGoogle Scholar
  5. 5.
    Wągrowska-Danilewicz M, Danilewicz M (1995) Glomerulonephritis associated with malignant diseases of non-renal origin. A report of three cases and a review of the literature. Pol J Pathol 46:195–198PubMedGoogle Scholar
  6. 6.
    Papper S (1984) Nephrotic syndrome and neoplasm. The findings to date, with practical implications. Postgrad Med 76:147–148PubMedGoogle Scholar
  7. 7.
    Davison AM (2001) Renal disease associated with malignancies. Nephrol Dial Transplant 16:13–14PubMedCrossRefGoogle Scholar
  8. 8.
    Posner MR, Prout MN, Berk S (1980) Thymoma and the nephrotic syndrome: a report of a case. Cancer 45:387–391PubMedCrossRefGoogle Scholar
  9. 9.
    Karras A, de Montpreville V, Fakhouri F, Grünfeld JP, Lesavre P (2005) Renal and thymic pathology in thymoma-associated nephropathy: report of 21 cases and review of the literature. Nephrol Dial Transplant 20:1075–1082PubMedCrossRefGoogle Scholar
  10. 10.
    Cameron JS, Ogg CS (1975) Neoplastic disease and the nephritic disease. Q J Med 44:630–631Google Scholar
  11. 11.
    Birkeland SA, Storm HH (2003) Glomerulonephritis and malignancy: a population-based analysis. Kidney Int 63:716–721PubMedCrossRefGoogle Scholar
  12. 12.
    Ahmed M, Solangi K, Abbi R, Adler S (1997) Nephrotic syndrome, renal failure, and renal malignancy: an unusual tumor-associated glomerulonephritis. J Am Soc Nephrol 8:848–852PubMedGoogle Scholar
  13. 13.
    Pescarmona E, Giardini R, Brisigotti M, Callea F, Piscane A, Baroni CD (1992) Thymoma in childhood: a clinico-pathological study of five cases. Histopathology 21:65–68PubMedCrossRefGoogle Scholar
  14. 14.
    Ogawa K, Toita T, Uno T, Fuwa N, Kakinohana Y, Kamata M, Koja K, Kinjo T, Adach G, Murayama S (2002) Treatment and prognosis of thymic carcinoma: a retrospective analysis of 40 cases. Cancer 94:3115–3119PubMedCrossRefGoogle Scholar

Copyright information

© IPNA 2007

Authors and Affiliations

  • Katarzyna Kiliś-Pstrusińska
    • 1
  • Anna Medyńska
    • 1
  • Danuta Zwolińska
    • 1
  • Grzegorz Dobaczewski
    • 2
  1. 1.Department of Paediatric NephrologyMedical UniversityWroclawPoland
  2. 2.Dept of Paediatric Bone Marrow Transplantation, Oncology and HaematologyMedical UniversityWroclawPoland

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