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Pediatric Nephrology

, Volume 22, Issue 11, pp 1911–1919 | Cite as

Evaluation of aortic stiffness in children with chronic renal failure

  • Ali Rahmi Bakiler
  • Onder YavascanEmail author
  • Nilgun Harputluoglu
  • Orhan Deniz Kara
  • Nejat Aksu
Original Article

Abstract

The measurement of aortic stiffness (As) [aortic strain (S), pressure strain elastic modulus (Ep) and pressure strain normalized by diastolic pressure (Ep*)] is suggested as an excellent marker of subclinical arterial sclerosis. We aimed to investigate the presence of As and to determine the relationship between As and some risk factors in children with chronic renal failure (CRF). Twenty-six pre-dialysis (PreD) [female/male (F/M) 7/19] patients and 23 chronic peritoneal dialysis (CPD) (F/M 13/10) patients were assessed. Twenty-nine healthy children were selected as a control group (F/M 14/15). We determined anemia, abnormal calcium/phosphate metabolism, hypertension, diastolic dysfunction, increased left ventricular mass (LVM), hypertriglyceridemia, increased stiffness (Ep, Ep*), and decreased strain (S) in the CRF (PreD and CPD) group compared with the controls (P < 0.05). Presence of renal disease, LVM and usage of angiotensin-converting enzyme inhibitor (ACE-I) in all groups; female gender, duration of disease and the usage of anti-hypertensive drug therapy in CRF patients; and LVM and LVM index in healthy children were found to be independent predictors for aortic stiffness and/or strain. In conclusion, CRF is associated with significant arterial functional abnormalities in uremic children and not controlled by dialysis treatment. These results suggest that, even in young children, uremia has a profound impact on arterial function.

Keywords

Aortic stiffness Cardiovascular assessment Chronic renal failure End-stage renal failure Children 

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Copyright information

© IPNA 2007

Authors and Affiliations

  • Ali Rahmi Bakiler
    • 1
  • Onder Yavascan
    • 2
    • 3
    Email author
  • Nilgun Harputluoglu
    • 1
  • Orhan Deniz Kara
    • 2
  • Nejat Aksu
    • 2
  1. 1.Department of Pediatric CardiologyTepecik Training and Research Hospital, YenisehirIzmirTurkey
  2. 2.Departments of Pediatric NephrologyTepecik Training and Research Hospital, YenisehirIzmirTurkey
  3. 3.9105/14 SokakIzmirTurkey

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