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Pediatric Nephrology

, Volume 22, Issue 9, pp 1297–1301 | Cite as

Screening for hypercalciuria in schoolchildren: what should be the criteria for diagnosis?

  • Mustafa KoyunEmail author
  • Ayfer Gür Güven
  • Serkan Filiz
  • Sema Akman
  • Halide Akbas
  • Yunus Emre Baysal
  • Necati Dedeoglu
Original Article

Abstract

The methodologies to diagnose hypercalciuria have not yet been standardized. The aims of this study were to assess the correlation between urinary calcium/creatinine ratio (UCa/Cr) ≥ 0.21 (mg/mg) and 24 h urinary calcium excretions and to determine the reference values of the UCa/Cr ratio among a large population of schoolchildren in southern Turkey. Non-fasting, second morning urine samples were collected from 2,143 children aged 7–14 years. In children with suspected hypercalciuria [UCa/Cr ≥ 0.21 (mg/mg)], 24 h urine samples were collected. The 95th percentile values of the UCa/Cr ratio for each age were calculated and showed a decrease in value with advancing age. In all, 269 (12.5%) of the children had UCa/Cr ≥ 0.21 (mg/mg), of whom 66 (24.5%) had daily urinary calcium excretion ≥4 mg/kg per day. A weak correlation was found between spot UCa/Cr ratios and daily urinary calcium excretions in children with UCa/Cr ≥ 0.21 (r = 0.27). We conclude that a spot UCa/Cr ratio of 0.21 (mg/mg) as the upper limit of normal cannot be used universally to define hypercalciuria. Age-specific reference values for UCa/Cr should be established for each population, to be used as a screening test for hypercalciuria, and the definite diagnosis should be established with 24 h urinary calcium excretion whenever possible.

Keywords

Hypercalciuria Urinary calcium-to-creatinine ratio 24 h urinary calcium excretion Percentile Schoolchildren 

Notes

Acknowledgments

The study was supported by a grant from the Scientific Research Fund of Akdeniz University.

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Copyright information

© IPNA 2007

Authors and Affiliations

  • Mustafa Koyun
    • 1
    • 2
    Email author
  • Ayfer Gür Güven
    • 2
  • Serkan Filiz
    • 3
  • Sema Akman
    • 2
  • Halide Akbas
    • 4
  • Yunus Emre Baysal
    • 1
  • Necati Dedeoglu
    • 5
  1. 1.Pediatric Nephrology, School of MedicineAkdeniz UniversityAntalyaTurkey
  2. 2.Department of Pediatric Nephrology, Medical FacultyAkdeniz UniversityAntalyaTurkey
  3. 3.Department of Pediatrics, School of MedicineAkdeniz UniversityAntalyaTurkey
  4. 4.Department of Biochemistry, School of MedicineAkdeniz UniversityAntalyaTurkey
  5. 5.Department of Public Health, School of MedicineAkdeniz UniversityAntalyaTurkey

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