Pediatric Nephrology

, 22:1373

Nephrotic syndrome preceding psoriasis in children

  • Arvind Bagga
  • Shina Menon
  • Pankaj Hari
  • Mukta Mantan
  • Amit Dinda
Brief Report

Abstract

Nephrotic syndrome is considered to be a late complication of psoriasis, reported usually in adults and characterized by IgA nephropathy or focal segmental glomerulosclerosis. We report on four children in whom steroid-resistant nephrotic syndrome either preceded (n = 3), by 41–120 months, or occurred simultaneously (n = 1) with psoriasis; renal histology showed minimal change disease. Therapy with corticosteroids and cyclosporine resulted in remission of renal and cutaneous symptoms. Minimal change nephrotic syndrome and psoriasis might share similar mechanisms of pathogenesis involving cell-mediated immunity.

Keywords

Cyclosporine Minimal change disease Psoriasis T lymphocytes 

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Copyright information

© IPNA 2007

Authors and Affiliations

  • Arvind Bagga
    • 3
  • Shina Menon
    • 1
  • Pankaj Hari
    • 1
  • Mukta Mantan
    • 1
  • Amit Dinda
    • 2
  1. 1.Division of Paediatric NephrologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of PathologyAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Division of Nephrology, Department of PaediatricsAll India Institute of Medical SciencesNew DelhiIndia

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