Pediatric Nephrology

, Volume 22, Issue 4, pp 597–599 | Cite as

Post streptococcal acute glomerulonephritis secondary to sporadic Streptococcus equi infection

  • Anna M. ThorleyEmail author
  • David Campbell
  • Nadeem E. Moghal
  • Sue Hudson
Brief Report


Streptococcus equi subspecies zooepidemicus infection is rare in humans, but a well-known cause of pyogenic disease in cows and horses. S. zooepidemicus uncommonly causes post-strep glomerulonephritis (PSGN) in humans via epidemic outbreaks. We present a sporadic case of post S. zooepidemicus glomerulonephritis in a child most probably contracted from a horse. The 14-year-old girl presented with the typical signs of PSGN, with S. equi zooepidemicus isolated from a blood culture, together with a low C3 and raised anti-DNAse B. This is the first known report of a sporadic case of PSGN in a child caused by this organism.


Streptococcus equi zooepidemicus Zoonosis Post-streptococcal glomerulonephritis 


  1. 1.
    Sweeney CR, Timoney JF, Newton JR, Hines MT (2005) Streptococcus equi infections in horses: guidelines for treatment, control and prevention of strangles. J Vet Intern Med 19:123–134PubMedCrossRefGoogle Scholar
  2. 2.
    Divers TJ, Timoney JF, Lewis RM, Smith CA (1992) Equine glomerulonephritis and renal failure associated with complexes of group C streptococcal antigen and IgG antibody. Vet Immunol Immunopathol 32:93–102PubMedCrossRefGoogle Scholar
  3. 3.
    Latorre M, Alvarez J, Fernandez M, Berdonces P, Llanos P, Cisterna R (1993) A case of meningitis due to Streptococcus zooepidemicus. Clin Infect Dis 17:932–933PubMedGoogle Scholar
  4. 4.
    Rose HD, Allen JR, Witte G (1980) Streptococcus zooepidemicus (group C) pneumonia in a human. J Clin Microbiol 11:76–78PubMedGoogle Scholar
  5. 5.
    Collazos J, Echevarria MJ, Ayarza R, Miguel J (1992) Streptococcus zooepidemicus septic arthritis: case report and review of group C streptococcal arthritis. Clin Infect Dis 15:744–746PubMedGoogle Scholar
  6. 6.
    Martinez-Luengas F, Inclan GM, Pastor A, Montejo M, Barron J, Baroja A, Aguirre C (1982) Endocarditis due to Streptococcus zooepidemicus. Can Med Assoc J 127:13PubMedGoogle Scholar
  7. 7.
    Balter S, Benin A, Pinto SWL, Teixeira LM, Alvim GG, Luna E, Jackson D, LaClaire L, Elliott J, Facklam R, Schuchat A (2000) Epidemic nephritis in Nova Serrana, Brazil. Lancet 355:1776–1780PubMedCrossRefGoogle Scholar
  8. 8.
    Barnham M, Thorton TJ, Lange K (1983) Nephritis caused by strep zooepidemicus (Lancefield Group C). Lancet 1:945–948PubMedCrossRefGoogle Scholar
  9. 9.
    Barnham M, Ljunggen A, McIntyre M (1987) Human infection with streptococcus zooepidemicus (Lancefield group C): three case reports. Epidemiol Infect 98:183–190PubMedCrossRefGoogle Scholar
  10. 10.
    Low DE, Young MR, Harding GKM (1980) Group C streptococcal meningitis in an adult: probably acquisition from a horse. Arch Intern Med 140:977–978PubMedCrossRefGoogle Scholar
  11. 11.
    Dodge WF, Spargo BH, Travis LB, Srivastava RN, Carvajal HF, DeBeukelaer MM, Longley MP, Menchaca JA (1972) Poststreptococcal glomerulonephritis. A prospective study in children. N Engl J Med 286:273–278, Feb 10CrossRefGoogle Scholar
  12. 12.
    Francis AJ, Nimmo GR, Efstratiou A, Galanis V, Nuttall N (1993) Investigation of milk-borne Streptococcus zooepidemicus infection associated with glomerulonephritis in Australia. J Infect 27:317–323PubMedCrossRefGoogle Scholar
  13. 13.
    Edwards AT, Roulson M, Ironside MJ (1988) A milk-borne outbreak of serious infection due to Streptococcus zooepidemicus (Lancefield group C). Epidemiol Infect 101:43–51PubMedCrossRefGoogle Scholar
  14. 14.
    Lange K, Ahmed U, Kleinberger H, Treser G (1976) A hitherto unknown streptococcal antigen and its probable relation to acute poststreptococcal glomerulonephritis. Clin Nephrol 5:207–215PubMedGoogle Scholar
  15. 15.
    Yoshizawa N, Yamazaki K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MDP (2004) Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. J Am Soc Nephrol 15:1785–1793PubMedCrossRefGoogle Scholar

Copyright information

© IPNA 2006

Authors and Affiliations

  • Anna M. Thorley
    • 1
    Email author
  • David Campbell
    • 2
  • Nadeem E. Moghal
    • 3
  • Sue Hudson
    • 1
  1. 1.Department of PaediatricsQueen Elizabeth HospitalGatesheadUK
  2. 2.Department of PaediatricsSunderland Royal HospitalSunderlandUK
  3. 3.Department of PaediatricsRoyal Victoria InfirmaryNewcastle upon TyneUK

Personalised recommendations