Pediatric Nephrology

, Volume 21, Issue 11, pp 1707–1715 | Cite as

Idiopathic membranous nephropathy in children

  • Beom Hee Lee
  • Hee Yeon Cho
  • Hee Gyung Kang
  • Il Soo Ha
  • Hae Il Cheong
  • Kyung Chul Moon
  • In Seok Lim
  • Yong ChoiEmail author
Original Article


Idiopathic membranous nephropathy (MN) is a rare cause of asymptomatic proteinuria (AP) or nephrotic syndrome (NS) in childhood. To improve our understanding of its clinical course, we retrospectively reviewed 19 cases of idiopathic MN seen in our hospital over a period of 28.5 years, i.e., from January 1977 to July 2005. Eight patients (39%) had AP and 11 (61%) presented with NS. All eight AP patients achieved remission, regardless of treatment modality. Oral corticosteroid was given to all 11 NS patients, but only three of them responded to corticosteroid. Of the eight steroid non-responders, three achieved remissions with the addition of cyclosporine, and the five who were not administered additional immunosuppressive drugs had persistent NS. At the latest evaluation, all six NS patients that achieved remission remained free of proteinuria and had a normal renal function. Moreover, two of the 5 steroid non-responders showed persistent nephrotic-range proteinuria but a stable renal function. The remaining three steroid non-responders progressed into chronic renal insufficiency, and this progression was preceded by renal vein thrombosis (RVT) in two of the three patients. Presentation with NS (P=0.045) and the development of RVT (P=0.010) were identified as poor prognostic factors.


Membranous nephropathy in children Asymptomatic proteinuria Nephrotic syndrome Corticosteroid Cyclosporine Renal vein thrombosis 


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Beom Hee Lee
    • 1
  • Hee Yeon Cho
    • 1
  • Hee Gyung Kang
    • 1
  • Il Soo Ha
    • 1
  • Hae Il Cheong
    • 1
  • Kyung Chul Moon
    • 2
  • In Seok Lim
    • 3
  • Yong Choi
    • 1
    Email author
  1. 1.Department of PediatricsSeoul National University Children’s HospitalSeoulSouth Korea
  2. 2.Department of PathologySeoul National University HospitalSeoulSouth Korea
  3. 3.Department of PediatricsChung Ang UniversitySeoulSouth Korea

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