Pediatric Nephrology

, Volume 21, Issue 10, pp 1492–1492 | Cite as

Syndrome of inappropriate antidiuretic hormone secretion and Kawasaki disease

  • Toru WatanabeEmail author
Letter to the Editors


Public Health Vasculitis Acute Phase Inflammatory Cytokine Antidiuretic Hormone 
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I read with interest the Letter to the Editor entitled “Kawasaki disease and hyponatremia” by Lee et al. [1]. The authors suggested that the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was one of the causes of hyponatremia in patients with Kawasaki disease (KD) and that serum cytokines such as interleukin (IL)-6 or IL-1 beta might contribute to the development of SIADH in such circumstances [1]. I agree with the comments of Dr. Lee et al. that SIADH has sometimes been reported in KD [2, 3] and cerebral vasculitis is thought to be a cause of SIADH in patients with KD [4]. On the other hand, Mine et al. recently suggested that inflammatory cytokines may be involved in the pathogenesis of SIADH in KD [5]. Many inflammatory cytokines, including IL-6 and IL-1 beta, are elevated during the acute phase of KD [4] and these cytokines may activate vasopressin secretion. As Dr. Lee et al. pointed out, further studies are necessary to confirm the possible relationship between serum cytokines and hyponatremia due to SIADH in KD [1], and there is a need to examine the various parameters, such as plasma vasopressin levels, concentrations of serum cytokines, serum osmolality, and urinary electrolytes and osmolality.


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    Shin JI, Kim JH, Lee JS, Kim DS, Choi JY, Sul JH (2006) Kawasaki disease and hyponatremia. Pediatr Nephrol Scholar
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    Lapointe N, Chad Z, Lacroix J, Jacob JL, Urbanski P, Polomeno R, Kupfert B, Courtecuisse V, Decary F (1982) Kawasaki disease: association with uveitis in seven patients. Pediatrics 69(3):376–379PubMedPubMedCentralGoogle Scholar
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    Mine K, Takaya J, Hasui M, Ikemoto Y, Teraguchi M, Kobayashi Y (2004) A case of Kawasaki disease associated with syndrome of inappropriate secretion of antidiuretic hormone. Acta Paediatr 93(11):1547–1549CrossRefGoogle Scholar

Copyright information

© IPNA 2006

Authors and Affiliations

  1. 1.Department of PediatricsNiigata City General HospitalNiigataJapan

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