Pediatric Nephrology

, Volume 21, Issue 11, pp 1698–1700 | Cite as

Rituximab therapy for steroid-dependent minimal change nephrotic syndrome

  • Rodney D. Gilbert
  • Eleanor Hulse
  • Susan Rigden
Brief Report


We present a patient with steroid-sensitive but high-dose steroid-dependent nephrotic syndrome who was treated with rituximab. For 9 months following therapy she had undetectable CD19 cells in the peripheral circulation. She remained in remission during this period even though therapy was reduced to low-dose, alternate day prednisolone only. After 9 months, CD19 cells were once again detectable. Shortly after CD19 cells became detectable again she relapsed. We conclude that B-lymphocytes play a central role in the pathogenesis of idiopathic minimal change nephrotic syndrome (MCNS) and that rituximab may have a useful role in the management of steroid-dependent patients.


Rituximab B-lymphocytes Nephrotic syndrome Steroid sensitivity Minimal change Drug therapy 


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Rodney D. Gilbert
    • 1
  • Eleanor Hulse
    • 1
  • Susan Rigden
    • 2
  1. 1.Regional Paediatric Nephro-Urology UnitChild Health Department Southampton General HospitalSouthamptonUK
  2. 2.Renal UnitEvelina Children’s Hospital, St. Thomas’s HospitalLondonUK

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