Pediatric Nephrology

, Volume 21, Issue 12, pp 1790–1801 | Cite as

Vitamin E in renal therapeutic regimens

Review

Abstract

Administration of vitamin E in children with immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis (FSGS) and type I diabetes demonstrated potential towards ameliorating progression. Oral vitamin E therapy reduced endothelial dysfunction, lipid peroxidation and oxidative stress in patients with chronic kidney failure (CKF). Moreover, the use of vitamin E-bonded hemodialyzers reduced atherosclerotic changes, erythropoietin dosage and muscular cramps in patients on hemodialysis (HD). However, several controlled clinical trials failed to document beneficial effects on the study subjects’ cardiovascular and renal outcomes. A recent report of increased all-cause mortality in adult patients receiving high dose vitamin E therapy has caused considerable concern and debate. These issues regarding the efficacy and safety of vitamin E in renal therapeutic regimens will be reviewed in this article.

Keywords

Vitamin E Alpha-tocopherol Glomerulosclerosis IgA nephropathy Chronic renal insufficiency 

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Copyright information

© IPNA 2006

Authors and Affiliations

  1. 1.University of AlexandriaAlexandriaEgypt
  2. 2.The Barbara Bush Children’s HospitalMaine Medical CenterPortlandUSA
  3. 3.University of VermontBurlingtonUSA

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