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Pediatric Nephrology

, Volume 21, Issue 10, pp 1434–1439 | Cite as

Paricalcitol versus calcitriol treatment for hyperparathyroidism in pediatric hemodialysis patients

  • Wacharee Seeherunvong
  • Obioma Nwobi
  • Carolyn L. AbitbolEmail author
  • Jayanthi Chandar
  • José Strauss
  • Gastón Zilleruelo
Original Article

Abstract

Secondary hyperparathyroidism (SHPT) remains a treatment dilemma in pediatric dialysis patients. Recent experience with paricalcitol (P), a vitamin D analogue, in adults with SHPT has shown equal efficacy and improved survival compared to traditional treatment with calcitriol (C). We present our experience with (C) compared to (P) treatment in our pediatric dialysis patients with SHPT. Twenty-one patients (mean age 11.5±5 years) with SHPT (intact parathyroid hormone (iPTH) averaging 1,228±496 pg/ml) were studied. Seventeen received (C) followed by (P); while an additional four were treated with either (C=1) or (P=3) alone. After 26±8 weeks, average percent (%) decrease in iPTH was similar with (C) and (P) (−60.4±34% versus −65.4±28%, respectively; p=0.6). In the (P) group, the effective dose in children was greater than in adult trials based on kilogram weight. Episodes of hypercalcemia between the treatment groups were not different. However, episodes of elevated calcium × phosphorus product (Ca×P)≥70 mg2/dl2 occurred more frequently in the (C) group (odds ratio=1.5; p=0.01). Paricalcitol appears to be safe and effective in pediatric patients. Data suggest that dosing should be gauged according to degree of SHPT. This should serve as impetus for future pharmacokinetic studies in pediatric dialysis patients.

Keywords

Paricalcitol Calcitriol Hyperparathyroidism Children Young adults Hemodialysis 

Notes

Acknowledgements

This study was supported in part by a grant from Florida’s Department of Health, Children’s Medical Services.

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Wacharee Seeherunvong
    • 1
  • Obioma Nwobi
    • 2
  • Carolyn L. Abitbol
    • 2
    Email author
  • Jayanthi Chandar
    • 2
  • José Strauss
    • 2
  • Gastón Zilleruelo
    • 2
  1. 1.Division of Pediatric Nephrology, Department of PediatricsRamathibodi Hospital, Mahidol UniversityBangkokThailand
  2. 2.Division of Pediatric Nephrology, Department of PediatricsUniversity of Miami/Holtz Children’s HospitalMiamiUSA

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