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Pediatric Nephrology

, Volume 21, Issue 9, pp 1312–1317 | Cite as

Nephrotic syndrome in a child after umbilical-cord-blood transplantation

  • Joo Hoon Lee
  • Bo Sang Kwon
  • Il Soo Ha
  • Hae Il Cheong
  • Kyung Chul Moon
  • Hyo Seop Ahn
  • Yong ChoiEmail author
Brief Report

Abstract

We report a 12-year-old girl who developed nephrotic syndrome 6 months after umbilical-cord-blood transplantation (UCBT) for acute lymphoblastic leukemia (L2). In addition to nephrotic syndrome, she also showed autoimmune hemolytic anemia, thrombocytopenia and gastrointestinal symptoms. Since these symptoms were manifested during the course of tapering immunosuppressive agents, a diagnosis of chronic graft-versus-host disease (GVHD) was made. Findings from a kidney biopsy were compatible with minimal-change disease (MCD), and focal glomerular capillary thrombosis and mild tubular damage were also noted. She was treated with methylprednisolone pulse therapy followed by oral prednisolone. Proteinuria disappeared in 14 days. Gastrointestinal symptoms, anemia and thrombocytopenia were also corrected. This is a case report of nephrotic syndrome as a manifestation of chronic GVHD developed after stem-cell transplantation. A review of the cases reported in the literature is also made.

Keywords

Nephrotic syndrome Stem-cell transplantation Chronic graft-versus-host disease 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Joo Hoon Lee
    • 1
  • Bo Sang Kwon
    • 2
  • Il Soo Ha
    • 2
  • Hae Il Cheong
    • 2
  • Kyung Chul Moon
    • 3
  • Hyo Seop Ahn
    • 2
    • 4
  • Yong Choi
    • 2
    Email author
  1. 1.Department of PediatricsAsan Medical CenterSeoulSouth Korea
  2. 2.Department of PediatricsSeoul National University Children’s HospitalSeoulSouth Korea
  3. 3.Department of Pediatrics and PathologySeoul National University Children’s HospitalSeoulSouth Korea
  4. 4.Cancer Research InstituteSeoul National University Children’s HospitalSeoulSouth Korea

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