Pediatric Nephrology

, Volume 21, Issue 8, pp 1138–1143 | Cite as

The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children

  • Graziela Lopes Del BenEmail author
  • Beata Marie Redublo Quinto
  • Dulce Elena Casarini
  • Luiz Carlos Bueno Ferreira
  • Sérgio Sousa Ayres
  • João Tomás de Abreu Carvalhaes
Original Article


The urinary activity of the angiotensin-converting enzyme (UACE) is not yet completely documented in human neonates. We measured the UACE in 36 premature neonates on the 1st day and in the 1st, 2nd, 3rd, and 4th weeks of life, in 22 full-term neonates between the 1st and 2nd days, and in 30 nursing and preschool children between 1 month and 6 years of age. The urinary excretion of sodium (UNa/UCr) and the potassium/sodium index (UK/UNa) were analyzed in the neonates. UACE was greater in premature than in full-term neonates and greater in both than in older children (p<0.001). In the premature neonates, UACE peaked at the 2nd week, the UNa/UCr index decreased, and the UK/UNa index increased between the 1st day and the 2nd week (p<0.001). The UNa/UCr index on the 1st day and in the 1st and 2nd weeks was greater in premature than in full-term neonates (p<0.001). There was no significant correlation between the UACE and the UNa/UCr index. In conclusion, the UACE profile was shown to be age dependent and related to the postnatal renal development. The increase in UACE activity may reflect the high activity of the neonatal intrarenal renin-angiotensin system (RAS).


Angiotensin-converting enzyme Peptidyl-dipeptidase Renin-angiotensin system Urinary sodium Premature Full-term Newborn 



This study was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP (96/00527-1).


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Graziela Lopes Del Ben
    • 1
    • 3
    • 4
    Email author
  • Beata Marie Redublo Quinto
    • 2
  • Dulce Elena Casarini
    • 2
  • Luiz Carlos Bueno Ferreira
    • 3
  • Sérgio Sousa Ayres
    • 3
  • João Tomás de Abreu Carvalhaes
    • 1
  1. 1.Pediatric Nephrology Division, Department of Pediatrics, Paulista Medical SchoolFederal University of São Paulo (UNIFESP)São PauloBrazil
  2. 2.Department of Internal Medicine, Nephrology Division, Paulista Medical SchoolFederal University of São Paulo (UNIFESP)São PauloBrazil
  3. 3.Neonatal Intensive Care UnitSão Luiz Hospital and MaternitySão PauloBrazil
  4. 4.Rua Benedito Lapin n°176 - Itaim BibiSão PauloBrazil

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