Pediatric Nephrology

, Volume 21, Issue 10, pp 1464–1470 | Cite as

Pediatric live-donor kidney transplantation in Mansoura Urology & Nephrology Center: a 28-year perspective

  • Amr A. El-HusseiniEmail author
  • Mohamed A. Foda
  • Mohamed A. Bakr
  • Ahmed A. Shokeir
  • Mohamed A. Sobh
  • Mohamed A. Ghoneim
Original Article


Our objective was to evaluate our overall experience in pediatric renal transplantation. Between March 1976 and March 2004, 1,600 live-donor kidney transplantations were carried out in our center; 216 of the patients were 18 years old or younger (mean age 12.9 years). There were 136 male patients and 80 female patients. The commonest causes of end-stage renal disease (ESRD) were renal dysplasia (22%), nephrotic syndrome (20%), hereditary nephritis (16%), and obstructive uropathy (16%). Of the donors, 94% were one-haplotype matched and the rest were identical. Pre-emptive transplantation was performed in 51 (23%) patients. Triple-therapy immunosuppression (prednisone + cyclosporine + azathioprine) was used in 78.2% of transplants. Rejection-free recipients constituted 47.7%. Hypertension (62%) was the commonest complication. A substantial proportion of patients (48%) were short, with height standard deviation score (SDS) less than −1.88. The overall infection rate was high, and the majority (53%) of infections were bacterial. The graft survival at 1 year, 5 years and 10 years were 93.4%, 73.3% and 48.2%, respectively, while the patients’ survival at 1, 5 and 10 years were 97.6%, 87.8% and 75.3%, respectively. Despite long-term success results of pediatric renal transplantation in a developing country, there is a risk of significant morbidity.


Children Kidney transplantation Live-donor Single-center 



The authors would like to thank Dr. Sherine Hamdy for her help in proofreading the article.


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Amr A. El-Husseini
    • 1
    Email author
  • Mohamed A. Foda
    • 1
  • Mohamed A. Bakr
    • 1
  • Ahmed A. Shokeir
    • 1
  • Mohamed A. Sobh
    • 1
  • Mohamed A. Ghoneim
    • 1
  1. 1.Mansoura Urology & Nephrology CenterMansoura UniversityMansouraEgypt

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