Pediatric Nephrology

, 21:672

Alterations of blood pressure in type 1 diabetic children and adolescents

  • Sukran Darcan
  • Damla Goksen
  • Sevgi Mir
  • Erkin Serdaroglu
  • Muammer Buyukinan
  • Mahmut Coker
  • Afig Berdeli
  • Timur Köse
  • Alphan Cura
Original Article

Abstract

The aim of this study was to assess the association between metabolic control, microalbuminuria, and diabetic nephropathy with ambulatory blood pressure monitoring (ABPM) in normotensive individuals with type 1 diabetes mellitus (DM). ABPM was undertaken in 68 normotensive type 1 diabetic patients with a mean age of 14.4±4.2 years. Microalbuminuria was diagnosed on the basis of a urinary albumin excretion rate grater than 20 μg/min in two of the three 24-h urine collections. Hypertension (HT) frequency was greater in the microalbuminuric patients than normoalbuminuric patients (54 vs 17.54%, p=0.05) with ABPM. Microalbuminuric patients had a higher diastolic pressure burden than normoalbuminuric patients. There were no differences in systolic and diastolic dips between the two groups. Diastolic pressure loads in all periods showed a significant correlation with duration of diabetes, mean HbA1c from the onset of diabetes, and level of microalbuminuria. Nocturnal dipping was reduced in 41.2% of the patients. In the normoalbuminuric group 41.1% and in the microalbuminuric group 63.6% were nondippers. Our data demonstrate higher 24-h and daytime diastolic blood pressure load and loss of nocturnal dip in type 1 diabetic adolescents and children. High diastolic blood pressure burden in diabetic patients could represent a risk for nephropathy.

Keywords

ABPM Diabetes Microalbuminuria Pediatrics 

Copyright information

© IPNA 2006

Authors and Affiliations

  • Sukran Darcan
    • 1
  • Damla Goksen
    • 2
  • Sevgi Mir
    • 2
  • Erkin Serdaroglu
    • 2
  • Muammer Buyukinan
    • 2
  • Mahmut Coker
    • 1
  • Afig Berdeli
    • 2
  • Timur Köse
    • 3
  • Alphan Cura
    • 2
  1. 1.Ege University Faculty of Medicine, Department of Pediatric Endocrinology and MetabolismIzmirTurkey
  2. 2.Ege University Faculty of Medicine, Department of Pediatric NephrologyIzmirTurkey
  3. 3.Ege University Faculty of Computer EngineeringIzmirTurkey

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