Pediatric Nephrology

, Volume 21, Issue 4, pp 577–579 | Cite as

Fanconi’s syndrome, interstitial fibrosis and renal failure by aristolochic acid in Chinese herbs

  • Yin-Tai Hong
  • Lin-Shien Fu
  • Lin-Huei Chung
  • Shien-Chung Hung
  • Yi-Ting Huang
  • Chin-Shiang Chi
Brief Report


Aristolochic acid-associated nephropathy (AAN) has been identified as a separate entity of progressive tubulo-interstitial nephropathy. Its characteristic pathological findings, including hypocellular interstitial fibrosis, intimal thickening of interlobular and afferent arterioles with glomeruli sparing or mild sclerosis, have been identified. Many cases of AAN in adults have been reported in Taiwan as well as throughout the world, but it has seldom been described in children. We report on a 10-year-old boy who presented with severe anemia, Fanconi’s syndrome, and progressive renal failure. Renal biopsy revealed typical findings of AAN. Aristolochic acids I and II were identified from a Chinese herb mixture ingested by the boy. AAN was diagnosed after other etiologies had been excluded. The case demonstrates the hazards of Chinese herbs with regard to children’s health in Taiwan and suggests that more attention should be paid to this issue.


Aristolochic acid-associated nephropathy Aristolochic acid Fanconi’s syndrome Interstitial nephropathy 



We are grateful to Dr. Chung-Shi Yang and Ms Pi-Ju Tsai, of the Department of Education and Research of Taichung Veterans’ General Hospital, for performing the analysis of the herbal mixture.


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Yin-Tai Hong
    • 1
  • Lin-Shien Fu
    • 1
  • Lin-Huei Chung
    • 1
  • Shien-Chung Hung
    • 1
  • Yi-Ting Huang
    • 2
  • Chin-Shiang Chi
    • 1
  1. 1.Division of Immunology and Nephrology, Department of PediatricsTaichung Veterans’ General HospitalTaichungTaiwan
  2. 2.Division of PediatricsChi Mei HospitalLiouyingTaiwan

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