Pediatric Nephrology

, Volume 21, Issue 4, pp 490–496

Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis

  • Jien-Wen Chien
  • Woan-Ling Chen
  • Yi-Giien Tsui
  • Min-Chun Lee
  • An-Yi Lin
  • Ching-Yuang Lin
Original Article

Abstract

Interleukin-11 (IL-11) is a multifunctional cytokine with both thrombopoietic and anti-inflammatory effects. In an animal study IL-11 was shown to reduce proteinuria in mice with necrotizing glomerulonephritis. The purpose of this current study is to explore the role of IL-11 in human glomerulonephritis. Subjects of this study were patients with proteinuria (daily urine protein excretion >40 mg/m2 per hour) and underlying pathology of IgA nephropathy (IgAN) (n=20), lupus nephritis (LN) (n=40), and idiopathic nephrotic syndrome (INS) (n=68). Daily urinary IL-11 level was measured by enzyme-linked immunosorbent assay (ELISA). Correlation between urinary IL-11 and urinary protein was determined by Pearson’s correlation coefficient. Another five patients with serial data of urinary protein, IL-11 and IL-11 messenger RNA (mRNA) expression in urine sediment are presented. The correlation between urinary IL-11 and daily urinary protein was significant for patients with IgAN (r=0.596, P=0.006) and LN (r=0.630, P<0.001), but not for patients with INS (r=0.030, P=0.812). Serial data revealed the same correlation. Furthermore, the peak of urinary IL-11 mRNA preceded that of urinary IL-11. We conclude that daily urinary IL-11 excretion is correlated with urinary protein loss in nephritis having local T helper (Th)1 predominant immune response, such as IgAN and LN. Local IL-11 production may serve as a counter cytokine against Th1-mediated inflammation.

Keywords

Idiopathic nephrotic syndrome IgA nephropathy Interleukin-11 Proteinuria Lupus nephritis Th1 disease Th2 disease 

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Jien-Wen Chien
    • 1
    • 2
  • Woan-Ling Chen
    • 1
  • Yi-Giien Tsui
    • 1
    • 3
  • Min-Chun Lee
    • 3
    • 4
  • An-Yi Lin
    • 1
  • Ching-Yuang Lin
    • 1
    • 3
  1. 1.Department of Pediatrics, Children’s HospitalChanghua Christian HospitalChanghuaTaiwan
  2. 2.Institute of Medical ResearchNational Yang-Ming UniversityTaipeiTaiwan
  3. 3.College of Health Sciences, Institute of Medical ResearchChang Jung Christian UniversityTainanTaiwan
  4. 4.Department of PediatricsBuddhist Tzu Chi General HospitalHualienTaiwan

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