Thin basement membrane nephropathy associated with minimal change disease in a 15-year-old boy
- 120 Downloads
Thin basement membrane nephropathy (TBMN) is characterized clinically by persistent hematuria, minimal proteinuria, normal renal function, another family member with hematuria, and a benign course. Especially in childhood TBMN, proteinuria of any degree is reported to be uncommon. We report on a boy with benign familial hematuria found by urinary screening at 3 years of age who presented with nephrotic syndrome (NS) at 15 years of age. His renal histology showed TBMN associated with minimal change disease (MCD). Treatment with corticosteroid resulted in complete remission of NS in a short period of time, while isolated hematuria persisted during the follow-up period despite this therapy. We speculate, therefore, that the nephrotic range proteinuria is not due to TBMN but rather is the manifestation of associated MCD. Several cases of TBMN with NS have been reported in adults, but it has not yet been reported in children in the literature. To our knowledge, this is the first case of childhood TBMN associated with NS resulting from coincidental MCD.
KeywordsThin basement membrane nephropathy Minimal change disease Nephrotic syndrome Children
The authors wish to thank Dr. Y. Sado (Shigei Medical Research Institute, Okayama, Japan) for staining for alpha 1–6 chains of type 4 collagen by indirect immunofluorescence methods.
- 8.Sado Y, Kagawa M, Kishiro Y, Sugihara K, Naito I, Seyer JM, Sugimoto M, Oohashi T, Ninomiya Y (1995) Establishment by the rat lymph node method of epitope-defined monoclonal antibodies recognizing the six different alpha chains of human type 4 collagen. Histochem Cell Biol 104:267–275CrossRefPubMedGoogle Scholar
- 9.[No authors listed] (1981) The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr 98:561–564Google Scholar