Pediatric Nephrology

, Volume 21, Issue 2, pp 277–280 | Cite as

Thin basement membrane nephropathy associated with minimal change disease in a 15-year-old boy

  • Shuichiro Fujinaga
  • Kazunari Kaneko
  • Yoshiyuki Ohtomo
  • Hitohiko Murakami
  • Mayako Takemoto
  • Masaru Takada
  • Toshiaki Shimizu
  • Yuichiro Yamashiro
Brief Report

Abstract

Thin basement membrane nephropathy (TBMN) is characterized clinically by persistent hematuria, minimal proteinuria, normal renal function, another family member with hematuria, and a benign course. Especially in childhood TBMN, proteinuria of any degree is reported to be uncommon. We report on a boy with benign familial hematuria found by urinary screening at 3 years of age who presented with nephrotic syndrome (NS) at 15 years of age. His renal histology showed TBMN associated with minimal change disease (MCD). Treatment with corticosteroid resulted in complete remission of NS in a short period of time, while isolated hematuria persisted during the follow-up period despite this therapy. We speculate, therefore, that the nephrotic range proteinuria is not due to TBMN but rather is the manifestation of associated MCD. Several cases of TBMN with NS have been reported in adults, but it has not yet been reported in children in the literature. To our knowledge, this is the first case of childhood TBMN associated with NS resulting from coincidental MCD.

Keywords

Thin basement membrane nephropathy Minimal change disease Nephrotic syndrome Children 

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Copyright information

© IPNA 2005

Authors and Affiliations

  • Shuichiro Fujinaga
    • 1
  • Kazunari Kaneko
    • 2
  • Yoshiyuki Ohtomo
    • 3
  • Hitohiko Murakami
    • 4
  • Mayako Takemoto
    • 3
  • Masaru Takada
    • 1
  • Toshiaki Shimizu
    • 3
  • Yuichiro Yamashiro
    • 3
  1. 1.Division of NephrologySaitama Children’s Medical CenterJapan
  2. 2.Department of PediatricsKansai Medical UniversityJapan
  3. 3.Department of PediatricsJuntendo University School of MedicineJapan
  4. 4.Division of PathologySaitama Children’s Medical CenterJapan

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