Pediatric Nephrology

, Volume 20, Issue 10, pp 1445–1448

Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis

  • Metin Kaya Gürgöze
  • Saadet Akarsu
  • Erdal Yilmaz
  • Ahmet Gödekmerdan
  • Zehra Akça
  • Ismail Çiftçi
  • A. Denizmen Aygün
Original Article

DOI: 10.1007/s00467-005-1941-6

Cite this article as:
Gürgöze, M.K., Akarsu, S., Yilmaz, E. et al. Pediatr Nephrol (2005) 20: 1445. doi:10.1007/s00467-005-1941-6

Abstract

This prospective study, performed in 76 children with a urinary tract infection (UTI), evaluates the diagnostic value of procalcitonin (PCT) and proinflammatory cytokines (IL-1β, IL-6 and TNF-α) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA). Renal parenchymal involvement was assessed by 99m Tc-DMSA scintigraphy within 7 days of admission. The diagnosis of acute pyelonephritis was confirmed only in patients with reversible lesions on scintigraphy. According to DMSA scan results, patients were divided into two groups, lower UTI or acute pyelonephritis. In acute pyelonephritis, serum PCT level was found to be significantly higher than it is in the lower UTI (p <0.001). Also, significantly higher serum proinflammatory cytokines (IL-1β, IL-6 and TNF-α) levels were detected in those with acute pyelonephritis than those with lower UTI (p <0.001). We conclude that both serum PCT and proinflammatory cytokine levels may be used as accurate markers for diagnosis of acute pyelonephritis.

Keywords

Acute phase reactant Acute pyelonephritis Children Procalcitonin Proinflammatory cytokines 

Copyright information

© IPNA 2005

Authors and Affiliations

  • Metin Kaya Gürgöze
    • 1
    • 4
  • Saadet Akarsu
    • 1
  • Erdal Yilmaz
    • 1
  • Ahmet Gödekmerdan
    • 2
  • Zehra Akça
    • 1
  • Ismail Çiftçi
    • 3
  • A. Denizmen Aygün
    • 1
  1. 1.Department of PediatricsFirat University Faculty of MedicineElazigTurkey
  2. 2.Department of ImmunologyFirat University Faculty of MedicineElazigTurkey
  3. 3.Department of Nuclear MedicineFirat University Faculty of MedicineElazigTurkey
  4. 4.Firat Universitesi Tıp FakultesiCocuk Sağlığı ve HastalıklarıElazigTurkey

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