Pediatric Nephrology

, Volume 20, Issue 6, pp 701–706 | Cite as

Alterations of leptin and ghrelin serum concentrations in renal disease: simple epiphenomena?

  • Jörg Dötsch
  • Kai Nüsken
  • Michael Schroth
  • Wolfgang Rascher
  • Udo Meißner
Editorial Commentary


The hypothesis that alterations of serum concentrations of the anorexigenic adipose tissue-derived hormone leptin or the orexigenic peptide ghrelin might help to regain appetite and fight malnutrition in patients with chronic renal failure cannot be confirmed at present. For the future, however, strategies interfering with signal transduction of these peptides in the hypothalamus might be more promising and should be investigated and further developed.


Leptin Ghrelin Dialysis Chronic renal failure Appetite 


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Copyright information

© IPNA 2005

Authors and Affiliations

  • Jörg Dötsch
    • 1
  • Kai Nüsken
    • 1
  • Michael Schroth
    • 1
  • Wolfgang Rascher
    • 1
  • Udo Meißner
    • 1
  1. 1.Klinik für Kinder und JugendlicheFriedrich-Alexander University ErlangenErlangenGermany

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