Serum VCAM-1, ICAM-1, and L-selectin levels in children and young adults with chronic renal failure
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Children and young adults with chronic renal failure (CRF) present with an impaired immune response. Our aim was to analyze whether leukocyte migration, determined by adhesion molecules, is disturbed in the course of CRF, hemodialysis (HD), and peritoneal dialysis (PD). Soluble (s) VCAM-1, ICAM-1, and L-selectin serum levels were evaluated by ELISA in 15 patients with CRF, 22 patients on cuprophane membrane HD, 24 patients on PD, and in 15 controls. The sVCAM-1 levels in all groups were significantly elevated compared with controls. The levels in HD patients were higher than in CRF patients (P <0.05), while levels in PD patients were higher than in CRF and HD (P <0.001 and P <0.01, respectively). The sICAM-1 concentrations in CRF and PD patients were significantly elevated compared with controls (P <0.001 and P <0.0001, respectively); in PD patients sICAM-1 levels were higher than in HD patients (P <0.001), but there were no differences between other groups. sL-selectin levels were decreased in all groups compared with controls. The levels in HD patients were the lowest and the differences, compared with CRF and PD patients, were significant (P <0.05 and P <0.01, respectively). Children and young adults with CRF and on maintenance dialysis have altered concentrations of soluble adhesion molecules, resulting from either inadequate clearance or disturbed synthesis and release. The differences in sVCAM-1 levels between CRF and both groups of patients on dialysis, as well as the differences in sL-selectin concentrations between HD and CRF patients, indicate that these disturbances are aggravated by maintenance dialysis, particularly HD.
KeywordsSoluble adhesion molecules Young adults Chronic renal failure Hemodialysis Peritoneal dialysis
A part of this work was presented at the ESPN Congress in Bilbao in 2002.
- 4.Springer TA (1997) Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. In: Leendert CP, Issekutz TB (eds) Adhesion molecules in health and disease. Marcel Dekker, New York, pp 1–54Google Scholar
- 17.Descamps-Latscha B, Herbelin A, Nguyen AT, Roux-Lombard P, Zingraff J, Moynot J, Verger C, Dahmane D, Groote D de, Jungers P, Dayer JM (1995) Balance between IL-1β, TNF-α and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells and monocytes. J Immunol 154:882–892PubMedGoogle Scholar