Advertisement

Pediatric Nephrology

, Volume 20, Issue 2, pp 239–240 | Cite as

Acute renal failure due to obstructive uric acid stones associated with rotavirus gastroenteritis

  • Shuichiro FujinagaEmail author
  • Kazunari Kaneko
  • Yoshiyuki Ohtomo
  • Masaru Takada
  • Kenichiro Kobayashi
  • Minoru Tada
  • Yuichiro Yamashiro
Letter to the Editors

Sirs,

The prevalence of urolithiasis in Japanese children is very low [1, 2]. Uric acid is rather uncommon as a constituent of childhood urolithiasis: uric acid stones occasionally develop in conditions associated with excessive production of uric acid, such as tumor lysis syndrome or lymphoproliferative/myeloproliferative disorders. Rare inborn errors of uric acid metabolism, i.e., complete or partial deficiencies of hypoxanthine-guanine phosphoribosyltransferase (HPRT) enzyme activity, named Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome, respectively [3, 4, 5], may be complicated by uric acid stones. We describe the first case of a previously healthy child with acute renal failure caused by obstructive uric acid stones of the bilateral pelviureteric junctions associated with rotavirus gastroenteritis.

A 13-month boy with an 8-day history of vomiting, watery diarrhea, and low-grade fever was initially admitted to a local hospital because of dehydration. On the following day, he...

Keywords

Urolithiasis Acute renal failure Rotavirus gastroenteritis 

References

  1. 1.
    Kaneko K, Tsuchiya K, Kawamura R, Ohtomo Y, Shimizu T, Yamashiro Y, Yamada T, Yamauchi K, Kitagawa T (2002) Low prevalence of hypercalciuria in Japanese children. Nephron 91:439–443CrossRefPubMedGoogle Scholar
  2. 2.
    Yoshida O, Terai A, Ohkawa T, Okada Y (1999) National trend of the incidence of urolithiasis in Japan from 1965 to 1995. Kidney Int 56:1899–1904CrossRefPubMedGoogle Scholar
  3. 3.
    Milliner DS (2003) Urolithiasis. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, pp 1091–1111Google Scholar
  4. 4.
    Ankem MK, Glazier DB, Brone JG (2000) Lesch-Nyhan syndrome presenting as acute renal failure secondary to obstructive uropathy. Urology 56:1056CrossRefGoogle Scholar
  5. 5.
    Hikita M, Hosoya T, Ichida K, Okabe H, Saji M, Ohno I, Kuriyama S, Tomonari H, Hayashi F, Onouchi K, Fujimori S, Yamaoka N, Sakuma R (1998) Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase manifesting as acute renal damage. Intern Med 37:945–949PubMedGoogle Scholar
  6. 6.
    Stapleton FB (1983) A screening test for hyperuricosuria. J Pediatr 102:88–90Google Scholar
  7. 7.
    Nishida Y, Miyamoto T (1986) Simple screening methods for hypoxanthine guanine phosphoribosyltransferase deficiencies using dried blood spots on filter paper. Ann Clin Biochem 23:55Google Scholar
  8. 8.
    Zhou Y, Li L, Kim B, Kaneshi K, Nishimura S, Kuroiwa T, Nishimura T, Sugita K, Ueda Y, Nakaya S, Ushijima H (2000) Rotavirus infection in children in Japan. Pediatr Int 42:428–439Google Scholar
  9. 9.
    Kovacs A, Chan L, Hotrakitya C, Overturf G, Portnoy B (1987) Rotavirus gastroenteritis. Clinical and laboratory features and use of Rotazyme test. Am J Dis Child 141:161–166PubMedGoogle Scholar

Copyright information

© IPNA 2004

Authors and Affiliations

  • Shuichiro Fujinaga
    • 1
    Email author
  • Kazunari Kaneko
    • 2
  • Yoshiyuki Ohtomo
    • 1
  • Masaru Takada
    • 1
  • Kenichiro Kobayashi
    • 3
  • Minoru Tada
    • 3
  • Yuichiro Yamashiro
    • 4
  1. 1.Division of NephrologySaitama Children’s Medical CenterJapan
  2. 2.Department of PediatricsJuntendo University Urayasu HospitalJapan
  3. 3.Division of UrologySaitama Children’s Medical CenterJapan
  4. 4.Department of PediatricsJuntendo School of MedicineJapan

Personalised recommendations