Pediatric Nephrology

, Volume 20, Issue 2, pp 239–240 | Cite as

Acute renal failure due to obstructive uric acid stones associated with rotavirus gastroenteritis

  • Shuichiro FujinagaEmail author
  • Kazunari Kaneko
  • Yoshiyuki Ohtomo
  • Masaru Takada
  • Kenichiro Kobayashi
  • Minoru Tada
  • Yuichiro Yamashiro
Letter to the Editors


The prevalence of urolithiasis in Japanese children is very low [1, 2]. Uric acid is rather uncommon as a constituent of childhood urolithiasis: uric acid stones occasionally develop in conditions associated with excessive production of uric acid, such as tumor lysis syndrome or lymphoproliferative/myeloproliferative disorders. Rare inborn errors of uric acid metabolism, i.e., complete or partial deficiencies of hypoxanthine-guanine phosphoribosyltransferase (HPRT) enzyme activity, named Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome, respectively [3, 4, 5], may be complicated by uric acid stones. We describe the first case of a previously healthy child with acute renal failure caused by obstructive uric acid stones of the bilateral pelviureteric junctions associated with rotavirus gastroenteritis.

A 13-month boy with an 8-day history of vomiting, watery diarrhea, and low-grade fever was initially admitted to a local hospital because of dehydration. On the following day, he...


Urolithiasis Acute renal failure Rotavirus gastroenteritis 


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Copyright information

© IPNA 2004

Authors and Affiliations

  • Shuichiro Fujinaga
    • 1
    Email author
  • Kazunari Kaneko
    • 2
  • Yoshiyuki Ohtomo
    • 1
  • Masaru Takada
    • 1
  • Kenichiro Kobayashi
    • 3
  • Minoru Tada
    • 3
  • Yuichiro Yamashiro
    • 4
  1. 1.Division of NephrologySaitama Children’s Medical CenterJapan
  2. 2.Department of PediatricsJuntendo University Urayasu HospitalJapan
  3. 3.Division of UrologySaitama Children’s Medical CenterJapan
  4. 4.Department of PediatricsJuntendo School of MedicineJapan

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