Congenital sodium diarrhea in a neonate presenting as acute renal failure
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Abstract
Congenital sodium diarrhea is a rare cause of secretory diarrhea due to a defect in the sodium/proton exchanger that results in decreased sodium absorption and increased excretion in stools. We report a pre-term baby boy with a birth weight of 1.4 kg who was referred because of rapidly rising serum urea and creatinine. The initially reported high urine output was later found to be severe watery diarrhea with severe oliguria and acute renal failure. Associated findings were normal anion gap metabolic acidosis with hyponatremia that required >50 mmol/kg of sodium per day for correction and about 300 ml/kg per day of replacement fluid to correct fluid and electrolyte abnormalities. The patient continues to do well 5 months after diagnosis.
Keywords
Congenital diarrhea Sodium diarrhea Acute tubular necrosis Metabolic acidosisReferences
- 1.Booth IW, Stange G, Murer H, Fenton TR, Milla PJ (1985) Defective jejunal brush border Na+/H+ exchange: a cause of congenital diarrhea. Lancet I:1066–1069CrossRefGoogle Scholar
- 2.Keller KM, Wirth S, Baumann W, Sule D, Booth IW (1990) Defective jejunal brush border membrane sodium/proton exchange in association with lethal familial protracted diarrhea. Gut 31:1156–1158PubMedGoogle Scholar
- 3.Muller T, Wijunenza C, Philipps AD, Janecke A, Houwen RH, Fischer H, Ellemunter H, Fruhcoirth M, Offner S, Muller W, Booth IW, Heinz-Erian P (2000) Congenital sodium diarrhea is an autosomal recessive disorder of sodium/proton exchange but unrelated to known candidate genes. Gastroenterology 119:1506–1513PubMedGoogle Scholar
- 4.Holmberg C, Perheentupa J (1985) Congenital Na+ diarrhea: a new type of secretory diarrhea. J Pediatr 106:56–61PubMedGoogle Scholar
- 5.Fell JM, Miller MP, Finkel Y, Booth IW (1992) Congenital sodium diarrhea with a partial defect in jejunal brush border membrane sodium transport, normal rectal transport, and resolving diarrhea. J Pediatr Gastroenterol Nutr 15:112–116PubMedGoogle Scholar
- 6.Kidowaki T, Funaki H, Mizuta R, Nishiki T, Takada H (1993) Treatment of an infant with congenital sodium diarrhea by oral rehydration. Acta Pediatr Jpn 35:49–52Google Scholar
- 7.Koh ET, Chan DK, Ho LY, Yeo CL (1998) Congenital sodium diarrhea in an Indian girl. Singapore Med J 39:468–470PubMedGoogle Scholar
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