Advertisement

Pediatric Nephrology

, Volume 19, Issue 2, pp 213–221 | Cite as

Renal replacement therapy in children: data from 12 registries in Europe

  • Bert J. van der Heijden
  • Paul C. W. van Dijk
  • Kate Verrier-Jones
  • Kitty J. JagerEmail author
  • J. Douglas Briggs
Original Article

Abstract

In June 2000 the ERA-EDTA Registry office moved to Amsterdam and started collecting core data on renal replacement therapy (RRT) entirely through national and regional registries. This paper reports the pediatric data from 12 registries. The analysis comprised 3,184 patients aged less than 20 years and starting RRT between 1980 and the end of 2000. The incidence of RRT rose from 7.1 per million of age-related population (pmarp) in the 1980–1984 cohort to 9.9 pmarp in the 1985–1989 cohort, and remained stable thereafter. The prevalence increased from 22.9 pmarp in 1980 to 62.1 in 2000. Hemodialysis was the commonest form of treatment at the start of dialysis, but peritoneal dialysis gained popularity during the late 1980s. Pre-emptive transplantation accounted for 18% of the first treatment modality in the 1995–2000 cohort. The relative risk of death of patients starting dialysis in the period 1995–2000 was reduced by 36% {adjusted hazard ratio (AHR) 0.64 [95% confidence interval (CI) 0.41–1.00]} and that of those receiving a first allograft by 42% [AHR 0.58 (95% CI 0.34–1.00)], compared with patients in the period 1980–1984. The prevalence of RRT in children has continued to rise, while its incidence has been stable for about 15 years. Patient survival has improved in both dialysis patients and transplant recipients. The development of this pediatric registry will form the basis for more-detailed and focused studies in the future.

Keywords

Dialysis Epidemiology Europe Registry Renal transplantation 

Notes

Acknowledgements.

We would like to thank the patients and staff of all the dialysis and transplant units who have contributed data via their national and regional renal registries. We also would like to thank the following registries for the contribution of these data: Austrian Dialysis and Transplant Registry (OEDTR), General Hospital of Wels, Wels, Austria (Dr. R. Kramar, Dr. H.K. Stumvoll); Dutch-speaking Belgian Registry (Dr. J. Donck, Ir H. Augustijn); French-Belgian Nephrologists Registry, Centre Hospitalier Etterbeek-Ixelles, Brussels, Belgium (Dr. F. Collart); Registry of Renal Patients (RMRC), Catalan Transplant Organization (OCATT), Barcelona, Spain (Dr. M. Clèries, Mr. E. Vela); Danish National Registry (Dr. H. Løkkegaard); Finnish Kidney Disease Registry and Department of Medicine, Helsinki University Hospital, Helsinki, Finland (Dr. C. Grönhagen-Riska, Dr. P. Finne); Greek National Registry, General Hospital of Athens G. Gennimatas, Athens, Greece (Dr. G.A. Ioannidis, Dr. N. Papagalanis); Icelandic Renal Registry, Landspitali—University Hospital, Reykjavik, Iceland (Dr. P. Asmundsson); Dutch End-Stage Renal Disease Registry (RENINE), Erasmus University Hospital, Rotterdam, The Netherlands (Dr. F.T. de Charro); Norwegian Renal Registry, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway (Dr. T. Leivestad); Scottish Renal Registry, Glasgow Royal Infirmary, Glasgow, Scotland, UK (Dr. K. Simpson); Swedish Registry for Active treatment of Uremia, Skövde, Sweden (Dr. J. Ahlmén, Dr. S. Schön) and the other ERA-EDTA Registry committee members and ERA-EDTA Registry staff members for their advice in the analysis and the drafting of this paper: Dr. G. Colasanti, Ir. R. Cornet, Dr. F.W. Dekker, Dr. C. Grönhagen-Riska, Dr. T. Feest, Dr. H.J. Schober-Halstenberg, Dr. K. Simpson, Dr. B. Stengel, and Dr. D. Tsakiris. The ERA-EDTA Registry is funded by the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA). The following companies have committed funds in the form of unrestricted educational grants to assist the ERA-EDTA in the financial support of the Registry: Amgen, Baxter, Fresenius Medical Care, Gambro, Hoffmann-La Roche, Hospal, Ortho-Biotech and Shire.

References

  1. 1.
    Mehls O, Rigden S, Ehrich JHH, Berthoux F, Jones EHP, Valderrabano F (1996) Report on management of renal failure in Europe, XXV, 1994. The child-adult interface. Nephrol Dial Transplant 11 [Suppl1]:22–36Google Scholar
  2. 2.
    Briggs JD, Jager KJ (2001) The first year of the new ERA-EDTA Registry. Nephrol Dial Transplant 16:1130–1131CrossRefPubMedGoogle Scholar
  3. 3.
    Dijk PCW van, Jager KJ, Charro F de, Collart F, Cornet R, Dekker FW, Grönhagen-Riska C, Kramar R, Leivestad T, Simpson K, Briggs JD (2001) Renal replacement therapy in Europe: the results of a collaborative effort by the ERA-EDTA registry and six national or regional registries. Nephrol Dial Transplant 16:1120–1129CrossRefPubMedGoogle Scholar
  4. 4.
    Finnish Registry for Kidney Diseases (1999) Report 1998, Helsinki, p 7Google Scholar
  5. 5.
    US Renal Data System (2001) USRDS 2001 Annual Data Report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, pp 107–116Google Scholar
  6. 6.
    Craig JC (2001) Paediatrics. In: Russ GR (ed) ANZDATA Registry Report 2001. Australia and New Zealand Dialysis and Transplant Registry, Adelaide, South Australia, pp 91–93Google Scholar
  7. 7.
    Neu AM, Ho PLM, McDonald RA, Warady BA (2002) Chronic dialysis in children and adolescents. The 2001 NAPRTCS Annual Report. Pediatr Nephrol 17:656–663Google Scholar
  8. 8.
    Goh D, Evans JHC, Houston IB, Mallick NP, Morton MJS, Johnson RWG, Postlethwaite RJ (1994) The changing pattern of children’s dialysis and transplantation over 20 years. Clin Nephrol 42:227–231PubMedGoogle Scholar
  9. 9.
    Reiss U, Wingen AM, Schärer K (1996) Mortality trends in pediatric patients with chronic renal failure. Pediatr Nephrol 10:41–45CrossRefPubMedGoogle Scholar
  10. 10.
    Groothoff JW, Gruppen MP, Offringa M, Hutten J, Lilien MR, Kar NJ van de, Wolff ED, Davin JC, Heymans HSA (2002) Mortality and causes of death of end-stage renal disease in children: a Dutch cohort study. Kidney Int 61:621–629CrossRefPubMedGoogle Scholar
  11. 11.
    Elshihabi I, Chavers B, Donaldson L, Emmett L, Tejani A (2000) Continuing improvement in cadaver donor graft survival in North American children. The 1998 Annual Report of the North American Renal Transplant Cooperative Study (NAPRTCS). Pediatr Transplant 4:235–246Google Scholar
  12. 12.
    Schärer K, Reiss U, Mehls O, Gretz N, Möhring K, Müller-Wiefel DE, Wingen A (1993) Changing pattern of chronic renal failure and renal replacement therapy in children and adolescents: a 20-year single center study. Eur J Pediatr 152:166–171PubMedGoogle Scholar

Copyright information

© IPNA 2004

Authors and Affiliations

  • Bert J. van der Heijden
    • 1
  • Paul C. W. van Dijk
    • 2
  • Kate Verrier-Jones
    • 3
  • Kitty J. Jager
    • 2
    • 4
    Email author
  • J. Douglas Briggs
    • 2
  1. 1.Sophia Children’s HospitalThe Netherlands
  2. 2.ERA-EDTA Registry, Department of Medical Informatics, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  3. 3.KRUF Children′s Kidney Center for WalesUniversity of Wales College of MedicineUK
  4. 4.ERA-EDTA Registry, Department of Medical Informatics, Academic Medical CenterUniversity of AmsterdamThe Netherlands

Personalised recommendations