Pediatric Nephrology

, Volume 19, Issue 2, pp 213–221 | Cite as

Renal replacement therapy in children: data from 12 registries in Europe

  • Bert J. van der Heijden
  • Paul C. W. van Dijk
  • Kate Verrier-Jones
  • Kitty J. JagerEmail author
  • J. Douglas Briggs
Original Article


In June 2000 the ERA-EDTA Registry office moved to Amsterdam and started collecting core data on renal replacement therapy (RRT) entirely through national and regional registries. This paper reports the pediatric data from 12 registries. The analysis comprised 3,184 patients aged less than 20 years and starting RRT between 1980 and the end of 2000. The incidence of RRT rose from 7.1 per million of age-related population (pmarp) in the 1980–1984 cohort to 9.9 pmarp in the 1985–1989 cohort, and remained stable thereafter. The prevalence increased from 22.9 pmarp in 1980 to 62.1 in 2000. Hemodialysis was the commonest form of treatment at the start of dialysis, but peritoneal dialysis gained popularity during the late 1980s. Pre-emptive transplantation accounted for 18% of the first treatment modality in the 1995–2000 cohort. The relative risk of death of patients starting dialysis in the period 1995–2000 was reduced by 36% {adjusted hazard ratio (AHR) 0.64 [95% confidence interval (CI) 0.41–1.00]} and that of those receiving a first allograft by 42% [AHR 0.58 (95% CI 0.34–1.00)], compared with patients in the period 1980–1984. The prevalence of RRT in children has continued to rise, while its incidence has been stable for about 15 years. Patient survival has improved in both dialysis patients and transplant recipients. The development of this pediatric registry will form the basis for more-detailed and focused studies in the future.


Dialysis Epidemiology Europe Registry Renal transplantation 



We would like to thank the patients and staff of all the dialysis and transplant units who have contributed data via their national and regional renal registries. We also would like to thank the following registries for the contribution of these data: Austrian Dialysis and Transplant Registry (OEDTR), General Hospital of Wels, Wels, Austria (Dr. R. Kramar, Dr. H.K. Stumvoll); Dutch-speaking Belgian Registry (Dr. J. Donck, Ir H. Augustijn); French-Belgian Nephrologists Registry, Centre Hospitalier Etterbeek-Ixelles, Brussels, Belgium (Dr. F. Collart); Registry of Renal Patients (RMRC), Catalan Transplant Organization (OCATT), Barcelona, Spain (Dr. M. Clèries, Mr. E. Vela); Danish National Registry (Dr. H. Løkkegaard); Finnish Kidney Disease Registry and Department of Medicine, Helsinki University Hospital, Helsinki, Finland (Dr. C. Grönhagen-Riska, Dr. P. Finne); Greek National Registry, General Hospital of Athens G. Gennimatas, Athens, Greece (Dr. G.A. Ioannidis, Dr. N. Papagalanis); Icelandic Renal Registry, Landspitali—University Hospital, Reykjavik, Iceland (Dr. P. Asmundsson); Dutch End-Stage Renal Disease Registry (RENINE), Erasmus University Hospital, Rotterdam, The Netherlands (Dr. F.T. de Charro); Norwegian Renal Registry, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway (Dr. T. Leivestad); Scottish Renal Registry, Glasgow Royal Infirmary, Glasgow, Scotland, UK (Dr. K. Simpson); Swedish Registry for Active treatment of Uremia, Skövde, Sweden (Dr. J. Ahlmén, Dr. S. Schön) and the other ERA-EDTA Registry committee members and ERA-EDTA Registry staff members for their advice in the analysis and the drafting of this paper: Dr. G. Colasanti, Ir. R. Cornet, Dr. F.W. Dekker, Dr. C. Grönhagen-Riska, Dr. T. Feest, Dr. H.J. Schober-Halstenberg, Dr. K. Simpson, Dr. B. Stengel, and Dr. D. Tsakiris. The ERA-EDTA Registry is funded by the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA). The following companies have committed funds in the form of unrestricted educational grants to assist the ERA-EDTA in the financial support of the Registry: Amgen, Baxter, Fresenius Medical Care, Gambro, Hoffmann-La Roche, Hospal, Ortho-Biotech and Shire.


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Copyright information

© IPNA 2004

Authors and Affiliations

  • Bert J. van der Heijden
    • 1
  • Paul C. W. van Dijk
    • 2
  • Kate Verrier-Jones
    • 3
  • Kitty J. Jager
    • 2
    • 4
    Email author
  • J. Douglas Briggs
    • 2
  1. 1.Sophia Children’s HospitalThe Netherlands
  2. 2.ERA-EDTA Registry, Department of Medical Informatics, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  3. 3.KRUF Children′s Kidney Center for WalesUniversity of Wales College of MedicineUK
  4. 4.ERA-EDTA Registry, Department of Medical Informatics, Academic Medical CenterUniversity of AmsterdamThe Netherlands

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