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Pediatric Nephrology

, Volume 17, Issue 5, pp 370–372 | Cite as

MPGN type I induced by granulocyte colony stimulating factor

  • D. Magen
  • Hana Mandel
  • Moshe Berant
  • Ofer Ben-Izhak
  • Israel Zelikovic
Brief Report

Abstract 

We report a girl with severe congenital neutropenia who has received long-term granulocyte-colony stimulating factor (G-CSF) therapy and has developed macroscopic hematuria, proteinuria, and decreased renal function associated with biopsy-proven membranoproliferative glomerulonephritis (MPGN) type I. Temporary discontinuation of G-CSF therapy as well as the use of glycosylated G-CSF has resulted in improvement in renal manifestations. We postulate that the MPGN was G-CSF- induced. Long-term G-CSF therapy should be used with great caution and close surveillance of kidney function.

Keywords Severe congenital neutropenia Kostmann disease Granulocyte-colony stimulating factor Membranoproliferative glomerulonephritis 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2002

Authors and Affiliations

  • D. Magen
    • 1
  • Hana Mandel
    • 2
  • Moshe Berant
    • 2
  • Ofer Ben-Izhak
    • 3
  • Israel Zelikovic
    • 1
  1. 1.Pediatric Nephrology Unit, Rambam Medical Center, P.O. Box 9602, Haifa 31096, Israel e-mail: d_magen@rambam.health.gov.il Tel.: +972-4-8543237, Fax: +972-4-8543473IL
  2. 2.Department of Pediatrics, Rambam Medical Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelIL
  3. 3.Department of Pathology, Rambam Medical Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelIL

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