Advertisement

Pediatric Nephrology

, Volume 17, Issue 6, pp 400–403 | Cite as

Long-term follow-up of Czech children with D+ hemolytic-uremic syndrome

  • Kveˇta Bláhová
  • J. Janda
  • Jirˇi Kreisinger
  • E. Mateˇjková
  • Anna Šedivá
Original Article

Abstract 

Fifty-seven children (f/m=31/26) who survived diarrhea (D) + hemolytic uremic syndrome (HUS) were evaluated. The examinations were performed 1–27 years (median 7 years) from the onset of the acute disease. Patients aged 2.3–27 years (median 10 years) were allocated to three groups: Recovery (R, complete recovery), Residual renal symptoms (RRS, hematuria and/or proteinuria and/or hypertension with glomerular filtration rate (GFR) >80 ml/min/1.73 m2, or moderate renal insufficiency with slightly decreased GFR to 60–80 ml/min/1.73 m2 with or without residual renal symptoms), and Chronic renal insufficiency/failure (CRI/F, dialysis, transplantation – GFR <60 ml/min/ 1.73 m2). Results from 18 patients who survived more than 10 years after HUS demonstrated a high prevalence of renal damage. Only 6/18 patients were in group R, 7/18 patients were in group RRS and 5/18 patients were in group CRI/F. An early onset of HUS (36 patients between 0 and 2 years) was associated with a better prognosis when compared with late onset (21 patients aged more than 2 years), P=0.009. Serology typing of Human leukocyte antigens (HLA) classes I and II in 64 patients revealed a significantly higher frequency of DR9 antigen (P=0.0037) and a lower frequency of DQ1 antigen (P=0.009) in D+HUS patients compared with healthy Czech blood donors. Conclusion: Our study demonstrates a high prevalence of late renal damage in Czech patients surviving after D+HUS. The HLA typing in our group revealed a significantly higher rate of HLA DR9 haplotypes in D+HUS patients.

Keywords Hemolytic-uremic syndrome Chronic renal failure Prognostic determinants HLA typing 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2002

Authors and Affiliations

  • Kveˇta Bláhová
    • 1
  • J. Janda
    • 1
  • Jirˇi Kreisinger
    • 1
  • E. Mateˇjková
    • 3
  • Anna Šedivá
    • 2
  1. 1.First Department of Pediatrics, Second Medical School, Prague, Czech RepublicCzech Republic
  2. 2.Department of Immunology, First Department of Pediatrics, Second Medical School, Prague, Czech RepublicCzech Republic
  3. 3.Institute of Hematology and Blood Transfusion, First Medical School, Prague, Czech RepublicCzech Republic

Personalised recommendations