Pediatric Nephrology

, Volume 17, Issue 4, pp 229–235

Recent insights into kidney diseases associated with glomerular cysts

  • A. S. Woolf
  • Sally A. Feather
  • Coralie Bingham
Developmental Biology Review

DOI: 10.1007/s00467-001-0819-5

Cite this article as:
Woolf, A., Feather, S. & Bingham, C. Pediatr Nephrol (2002) 17: 229. doi:10.1007/s00467-001-0819-5

Abstract

Glomerular cysts can exist in the context of several different kidney diseases. Advances in the last few years have begun to unravel the genetic bases and pathogenesis of some of these entities, many of which have an origin in abnormal development. In this review, we highlight recent insights into three types of disease associated with glomerular cysts: (1) mutations of the hepatocyte nuclear factor 1β(HNF-1β) in the recently described renal cysts and diabetes syndrome, (2) mutations of OFD1 in the oral facial digital syndrome type 1 and (3) the role of fetal urinary tract obstruction.

Keywords Fetal kidney obstruction Hepatocyte nuclear factor 1β (HNF-1β) Glomerulocystic kidney disease Oral facial digital syndrome 1 (OFD1) Renal cysts and diabetes (RCAD) syndrome Renal dysplasia 

Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2002

Authors and Affiliations

  • A. S. Woolf
    • 1
  • Sally A. Feather
    • 1
  • Coralie Bingham
    • 3
  1. 1.Nephro-Urology Unit, Room 219, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK e-mail: a.woolf@ich.ucl.ac.uk Tel.: +44-20-79052615, Fax: +44-20-79160011UK
  2. 2.Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UKUK
  3. 3.Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, UKUK

Personalised recommendations