Pediatric Nephrology

, Volume 17, Issue 3, pp 181–183 | Cite as

Varicella vaccination in children with steroid-sensitive nephrotic syndrome

  • Harika Alpay
  • Nurdan Yıldız
  • Aydın Onar
  • H. Temizer
  • Sevil Özçay
Original Article

Abstract 

We have studied serological and clinical response to live, attenuated varicella zoster virus (VZV) vaccine (Varilrix, SmithKline Beecham) in 20 patients with steroid-sensitive nephrotic syndrome (SSNS) in remission and 22 normal controls who had no history of varicella and no detectable antibody to VZV. Nephrotic patients included 15 boys and 5 girls, with a mean age of 4.7 years (range 2–11.4 years). The controls were healthy age-matched children (13 girls and 9 boys). Seventeen patients with SSNS (85%) and 19 healthy controls (86%) seroconverted 8 weeks after vaccination. One patient with SSNS had a relapse 20 days after vaccination, and 1 child in the control group had a rash. Two years after vaccination, antibodies to VZV were detected in 12 of 17 responders, 2 of 3 non-responders, and 13 of 22 controls. Within 2 years of vaccination, 3 of the vaccine responder children with SSNS had a mild varicella infection. Two responder and 1 non-responder nephrotic children and 9 controls were lost to long-term follow-up. Our results show that immunization with a single dose of VZV vaccine is safe and effective in children with SSNS in remission.

Keywords Varicella zoster virus Vaccines Nephrotic syndrome Corticosteroids Immunization 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2002

Authors and Affiliations

  • Harika Alpay
    • 1
  • Nurdan Yıldız
    • 2
  • Aydın Onar
    • 2
  • H. Temizer
    • 3
  • Sevil Özçay
    • 2
  1. 1.Department of Pediatric Nephrology, Marmara University, Faculty of Medicine, Istanbul, TurkeyTurkey
  2. 2.Department of Pediatric Nephrology, SSK Göztepe Hospital, Istanbul, TurkeyTurkey
  3. 3.Microbiology Laboratory, SSK Göztepe Hospital, Istanbul, TurkeyTurkey
  4. 4.Atas¸ehir 48. Ada Mimoza 2/6 D:11 K.Bakkalköy, Istanbul, Turkey e-mail:mstar@ixir.com Fax: +90-216-4553589Turkey

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